Bose S, Kapila K, Verma K
Department of Pathology, All India Institute of Medical Sciences, New Delhi.
Diagn Cytopathol. 1992;8(1):28-32. doi: 10.1002/dc.2840080107.
The cytomorphological features of 38 cases of medullary carcinoma of the thyroid on FNAC were studied. These cases were retrieved from the files of the cytopathology laboratory. In addition, staining for calcitonin (19 cases), thyroglobulin (5 cases), neurone specific enolase (7 cases), and carcinoembryonic antigen (8 cases) was done. Electron microscopy was done in two cases. On morphology, the presence of amyloid together with cytoplasmic granules was found to be diagnostic. The plasmacytoid cell type and the mixed cell populations were most commonly observed. Pseudononuclear inclusions were seen in 58% of cases. Calcitonin was present in 74% of cases. NSE was noncontributory, whereas CEA was positive in one of the calcitonin negative cases.
对38例经细针穿刺抽吸活检（FNAC）诊断的甲状腺髓样癌的细胞形态学特征进行了研究。这些病例取自细胞病理学实验室档案。此外，对19例进行了降钙素染色，5例进行了甲状腺球蛋白染色，7例进行了神经元特异性烯醇化酶染色，8例进行了癌胚抗原染色。对2例进行了电子显微镜检查。在形态学上，发现淀粉样物质与细胞质颗粒并存具有诊断意义。最常观察到浆细胞样细胞类型和混合细胞群体。58%的病例可见假核内包涵体。74%的病例降钙素呈阳性。神经元特异性烯醇化酶无诊断价值，而在1例降钙素阴性病例中癌胚抗原呈阳性。
