Haskard D O
The Eric Bywaters Centre for Vascular Inflammation, Imperial College London, Hammersmith Hospital, United Kingdom.
Scand J Rheumatol. 2004;33(5):281-92. doi: 10.1080/03009740410010281.
Over recent years it has become clear that patients with inflammatory rheumatic diseases are at increased risk of developing atherosclerosis. The exact causes for this are probably related in part to a general adverse effect of inflammation on atherogenesis, and in part to immune mechanisms specific to individual rheumatic diseases. This review discusses proposed mechanisms of accelerated atherosclerosis, including abnormal lipid and lipoprotein profiles, oxidative stress, enhanced apoptosis, thrombophilia, immune complexes, and increased mononuclear cell infiltration of atherosclerotic lesions, and local generation of cytokines.
近年来，有一点已经很清楚，即患有炎性风湿性疾病的患者患动脉粥样硬化的风险增加。造成这种情况的确切原因可能部分与炎症对动脉粥样硬化发生的一般不良影响有关，部分与个别风湿性疾病特有的免疫机制有关。这篇综述讨论了动脉粥样硬化加速发展的可能机制，包括异常的脂质和脂蛋白谱、氧化应激、细胞凋亡增加、血栓形成倾向、免疫复合物、动脉粥样硬化病变中单核细胞浸润增加以及细胞因子的局部产生。
