Doria Andrea, Sherer Yaniv, Meroni Pier L, Shoenfeld Yehuda
Division of Rheumatology, Department of Medical and Surgical Science, University of Padua, Via Guistiniani 2, 35128 Padua, Italy.
Rheum Dis Clin North Am. 2005 May;31(2):355-62, viii. doi: 10.1016/j.rdc.2005.01.006.
This article summarizes knowledge of the pathogenic mechanisms in autoimmune rheumatic diseases as risk factors for accelerated atherosclerosis. The studies described support a role for immunologic-inflammatory mechanisms in the pathogenesis of atherosclerosis. This immunologic-inflammatory state is evident in many autoimmune diseases, but also in the general population lacking an overt autoimmune disease. The ability to immunomodulate atherosclerosis (currently only experimental) should lead to future research into the mechanisms and treatment of atherosclerosis, the leading cause of death in the Western world.
本文总结了自身免疫性风湿性疾病作为动脉粥样硬化加速危险因素的致病机制相关知识。所描述的研究支持免疫炎症机制在动脉粥样硬化发病机制中的作用。这种免疫炎症状态在许多自身免疫性疾病中很明显，但在没有明显自身免疫性疾病的普通人群中也存在。免疫调节动脉粥样硬化的能力（目前仅处于实验阶段）应会引发对动脉粥样硬化机制和治疗方法的进一步研究，动脉粥样硬化是西方世界的主要死因。
