Kim Dong-Hwan, Abidian Mohammad, Martin David C
Biomedical Engineering, The University of Michigan, Ann Arbor, Michigan 48109, USA.
J Biomed Mater Res A. 2004 Dec 15;71(4):577-85. doi: 10.1002/jbm.a.30124.
The conducting polymer polypyrrole (PPy) was electrochemically grown on hydrogel scaffolds deposited on the surface of microfabricated neural prosthetic devices. It is shown that the pyrrole monomer can be grown vertically through the hydrogel layer up to the surface without affecting the adjacent sites on the probes. The electrochemical properties of the conducting polymer-modified hydrogels were studied by impedance spectroscopy and cyclic voltammetry. It is also found that the conducting polymers could still be readily grown through the hydrogel after the microstructure is disrupted by freeze drying. Impedance measurements at the biologically important frequency of 1 kHz showed that the minimum impedance of this polymer-modified hydrogel was 7 kOmega. This is much lower than the minimum impedance of polypyrrole film ( approximately 100 kOmega).
导电聚合物聚吡咯（PPy）通过电化学方法生长在微纳加工神经假体装置表面沉积的水凝胶支架上。结果表明，吡咯单体能够垂直生长穿过水凝胶层直至表面，而不会影响探针上的相邻位点。通过阻抗谱和循环伏安法研究了导电聚合物修饰水凝胶的电化学性质。还发现，在通过冷冻干燥破坏微观结构后，导电聚合物仍能很容易地穿过水凝胶生长。在生物学重要频率1kHz下的阻抗测量表明，这种聚合物修饰水凝胶的最小阻抗为7kΩ。这远低于聚吡咯膜的最小阻抗（约100kΩ）。
