用吡咯-透明质酸共轭物对神经电极进行表面修饰以减轻体内反应性星形胶质细胞增生。

Surface modification of neural electrodes with pyrrole-hyaluronic acid conjugate to attenuate reactive astrogliosis in vivo.

作者信息

Lee J Y, Khaing Z Z, Siegel J J, Schmidt C E

机构信息

Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, USA.

School of Materials Science and Engineering, Gwangju Institute of Science and Engineering, Gwangju, South Korea.

出版信息

RSC Adv. 2015;5(49):39228-39231. doi: 10.1039/c5ra03294f. Epub 2015 Apr 22.

DOI:10.1039/c5ra03294f

PMID:35528963

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9075707/

Abstract

Surface of neural probes were electrochemically modified with a non-cell adhesive and biocompatible conjugate, pyrrole-hyaluronic acid (PyHA), to reduce reactive astrogliosis. Poly(PyHA)-modified wire electrodes were implanted into rat motor cortices for three weeks and were found to markedly reduce the expression of glial fibrillary acidic protein compared to uncoated electrodes.

摘要

神经探针表面通过一种非细胞黏附且具有生物相容性的共轭物吡咯-透明质酸（PyHA）进行电化学修饰，以减少反应性星形胶质细胞增生。将聚（PyHA）修饰的线电极植入大鼠运动皮层三周，结果发现与未涂层电极相比，其能显著降低胶质纤维酸性蛋白的表达。