Marusić-Galesić S, Marusić M, Pokrić B
Ruder Bosković Institute, Bijenicka, Croatia.
Immunology. 1992 Feb;75(2):325-9.
Recently, it was shown that 10(2)- to 10(3)-fold lower doses of human serum albumin (HSA) are sufficient for the same T-cell response in vitro, if HSA is administered to the cultures bound in the immune complex rather than in the soluble form. In the present study, we analysed the capacity of HSA in the form of immune complexes to elicit specific cellular immune response in vivo. We found that antigen bound in the immune complex with murine, syngeneic polyclonal antibodies elicited the same T-cell response as fivefold higher doses of free antigen. On the other hand, HSA bound in the immune complexes with xenogeneic, rabbit polyclonal antibodies did not enhance anti-HSA cellular immune response. Our results indicate that binding of antigen in the immune complex could play an important role in enhancing an antigen-specific cellular immune response in vivo.
最近研究表明，如果将人血清白蛋白（HSA）以免疫复合物形式而非可溶性形式添加到培养物中，体外产生相同T细胞反应所需的HSA剂量可降低10²至10³倍。在本研究中，我们分析了免疫复合物形式的HSA在体内引发特异性细胞免疫反应的能力。我们发现，与鼠源同基因多克隆抗体结合在免疫复合物中的抗原引发的T细胞反应，与五倍剂量的游离抗原相同。另一方面，与异种兔多克隆抗体结合在免疫复合物中的HSA并未增强抗HSA细胞免疫反应。我们的结果表明，抗原与免疫复合物的结合在增强体内抗原特异性细胞免疫反应中可能起重要作用。
