Marusić M, Marusić-Galesić S, Pokrić B
Medical Center Paprikovac, Banja Luka, Bosnia.
Immunol Invest. 1992 Dec;21(7):623-8. doi: 10.3109/08820139209069398.
Antigen (HSA) bound in immune complexes at equivalence with syngeneic anti-HSA antibodies elicit much stronger humoral immune response then soluble HSA. On the other hand, administration of immune complexes formed with xenogeneic (rabbit) anti-HSA antibodies suppressed humoral immune response against HSA, but not against rabbit IgG in mice. We suggest that immunization with antigen bound in immune complex might represent a powerful tool in enhancing humoral immune responses.
与同基因抗人血清白蛋白（HSA）抗体处于等价状态的免疫复合物中结合的抗原，引发的体液免疫反应比可溶性HSA更强。另一方面，用异种（兔）抗HSA抗体形成的免疫复合物给药可抑制小鼠针对HSA的体液免疫反应，但不抑制针对兔IgG的体液免疫反应。我们认为，用免疫复合物中结合的抗原进行免疫可能是增强体液免疫反应的有力工具。
