Baecher-Allan Clare, Hafler David A
Harvard Medical School, 77 Ave. Louis Pasteur, Boston, MA 02115, USA.
J Exp Med. 2004 Aug 2;200(3):273-6. doi: 10.1084/jem.20040812. Epub 2004 Jul 26.
Although central and peripheral tolerance are important for the regulation of human immune responses to self- and microbial antigens, an important role of suppressor CD4(+) CD25(+) T cells is suggested from the recent investigations of human autoimmune diseases and HIV. These new data provide increasing evidence that altered function of CD4(+) CD25(+) T cells may be an important factor in a wide range of human inflammatory and infectious diseases.
尽管中枢和外周耐受对于调节人类针对自身抗原和微生物抗原的免疫反应很重要，但近期对人类自身免疫性疾病和艾滋病的研究表明，抑制性CD4(+) CD25(+) T细胞具有重要作用。这些新数据提供了越来越多的证据，表明CD4(+) CD25(+) T细胞功能改变可能是多种人类炎症性和感染性疾病的一个重要因素。
