Tongren Jon Eric, Zavala Fidel, Roos David S, Riley Eleanor M
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Trends Parasitol. 2004 Dec;20(12):604-10. doi: 10.1016/j.pt.2004.09.005.
The Roll Back Malaria campaign vowed to halve the global burden of malaria in ten years but, midway into that campaign, few new malaria control tools have been introduced, and many established methods appear to be failing with effective chemotherapy being perhaps the most problematic. It has been repeatedly argued that the discovery and implementation of a safe and effective vaccine against malaria is a major priority in the control of the disease. Indeed, many malaria control experts believe that sustainable reductions in malaria control will be nigh on impossible in the absence of such a vaccine. While most would agree that we are still some way from being able to introduce a vaccine, steady progress is being made. We review here some new approaches and developments in vaccine research that were discussed at the Molecular Approaches to Malaria conference held 1-5 February 2004 in Lorne, Australia.
遏制疟疾运动誓言要在十年内将全球疟疾负担减半，但在该运动进行到一半时，几乎没有引入新的疟疾控制工具，而且许多既定方法似乎正在失效，其中有效的化疗可能是问题最大的。人们一再强调，发现并实施一种安全有效的疟疾疫苗是控制该疾病的首要任务。事实上，许多疟疾控制专家认为，没有这种疫苗，要持续降低疟疾发病率几乎是不可能的。虽然大多数人都认同我们距离能够推出一种疫苗仍有一段路要走，但正在取得稳步进展。我们在此回顾2004年2月1日至5日在澳大利亚洛恩举行的疟疾分子方法会议上讨论的疫苗研究的一些新方法和新进展。
