β2-微球蛋白缺陷小鼠的皮肤移植排斥反应。
Skin graft rejection by beta 2-microglobulin-deficient mice.
作者信息
Zijlstra M, Auchincloss H, Loring J M, Chase C M, Russell P S, Jaenisch R
机构信息
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts.
出版信息
J Exp Med. 1992 Apr 1;175(4):885-93. doi: 10.1084/jem.175.4.885.
Abstract
Mice homozygous for a beta 2-microglobulin (beta 2-m) gene disruption lack beta 2-m protein and are deficient for functional major histocompatibility complex class I (MHC-I) molecules. The mutant mice have normal numbers of CD4+8- T helper cells, but lack MHC-I-directed CD4-8+ cytotoxic T lymphocytes (CTLs). In this study we used the beta 2-m mutant mice to study the importance of MHC-I-directed immunity in skin graft rejection. Our results indicate that MHC-I-directed CD8+ CTLs are not essential in the rejection of allografts with whole MHC or multiple minor H differences. However, the absence of MHC-I-guided immunity profoundly reduces the ability of mutant mice to reject H-Y disparate grafts. In addition, we show that natural killer cells which vigorously reject MHC-I-deficient bone marrow grafts, are not effective in the destruction of MHC-I-deficient skin grafts.
摘要
纯合子β2-微球蛋白（β2-m）基因敲除小鼠缺乏β2-m蛋白，且功能性主要组织相容性复合体I类（MHC-I）分子存在缺陷。该突变小鼠的CD4+8-T辅助细胞数量正常，但缺乏MHC-I导向的CD4-8+细胞毒性T淋巴细胞（CTL）。在本研究中，我们使用β2-m突变小鼠来研究MHC-I导向免疫在皮肤移植排斥反应中的重要性。我们的结果表明，MHC-I导向的CD8+CTL在具有完整MHC或多个次要组织相容性抗原差异的同种异体移植排斥反应中并非必不可少。然而，缺乏MHC-I导向的免疫会显著降低突变小鼠排斥H-Y不相合移植的能力。此外，我们发现，能强烈排斥MHC-I缺陷骨髓移植的自然杀伤细胞，在破坏MHC-I缺陷皮肤移植方面并不有效。
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本文引用的文献
1
Cells mediating graft rejection in the mouse. III. Ly-1+ precursor T cells generate skin graft rejection.介导小鼠移植物排斥反应的细胞。III. Ly-1⁺前体T细胞引发皮肤移植物排斥反应。
Transplantation. 1982 Apr;33(4):407-10. doi: 10.1097/00007890-198204000-00013.
2
The key role of Lyt-1+ cells in skin graft rejection in the mouse.Lyt-1+细胞在小鼠皮肤移植排斥反应中的关键作用。
Transplant Proc. 1981 Mar;13(1 Pt 2):1079-81.
3
Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection.介导小鼠移植物排斥反应的细胞。I. Lyt-1细胞介导皮肤移植物排斥反应。
J Exp Med. 1981 May 1;153(5):1044-57. doi: 10.1084/jem.153.5.1044.
4
5
Non-H-2 and H-2-linked immune response genes control the cytotoxic T-cell response to H-Y.非H-2和H-2连锁免疫反应基因控制细胞毒性T细胞对H-Y的反应。
Immunogenetics. 1982 Mar;15(3):261-70. doi: 10.1007/BF00364334.
6
Establishment of monoclonal anti-Nk-1.1 antibody.抗Nk-1.1单克隆抗体的制备
Hybridoma. 1984 Fall;3(3):301-3. doi: 10.1089/hyb.1984.3.301.
7
Variable expression of Ia antigens on the vascular endothelium of mouse skin allografts.小鼠皮肤同种异体移植血管内皮上Ia抗原的可变表达。
Nature. 1983;303(5916):426-9. doi: 10.1038/303426a0.
8
A reexamination of the role of LYT-2-positive T cells in murine skin graft rejection.对LYT-2阳性T细胞在小鼠皮肤移植排斥反应中作用的重新审视。
J Exp Med. 1984 Jan 1;159(1):57-67. doi: 10.1084/jem.159.1.57.
9
Cloned LYT-2+ cytolytic T lymphocytes destroy allogeneic tissue in vivo.克隆化的LYT-2+细胞毒性T淋巴细胞在体内可破坏同种异体组织。
J Exp Med. 1984 Jan 1;159(1):234-43. doi: 10.1084/jem.159.1.234.
10
Characterization of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T cell clones appears to correlate primarily with class II MHC antigen-reactivity.被单克隆抗体GK1.5识别的、命名为L3T4a的鼠类抗原决定簇的特性：功能性T细胞克隆对L3T4a的表达似乎主要与II类主要组织相容性复合体（MHC）抗原反应性相关。
Immunol Rev. 1983;74:29-56. doi: 10.1111/j.1600-065x.1983.tb01083.x.
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