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监测猪胰岛异种移植受体中潜在的外来病毒的存在情况。

Monitoring for presence of potentially xenotic viruses in recipients of pig islet xenotransplantation.

作者信息

Garkavenko O, Croxson M C, Irgang M, Karlas A, Denner J, Elliott R B

机构信息

Diatranz NZ Ltd., P.O. Box 23566, Papatoetoe, Auckland, New Zealand.

出版信息

J Clin Microbiol. 2004 Nov;42(11):5353-6. doi: 10.1128/JCM.42.11.5353-5356.2004.

DOI:10.1128/JCM.42.11.5353-5356.2004
PMID:15528741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC525280/
Abstract

This study represents a long-term follow-up of human patients receiving pig islet xenotransplantation. Eighteen patients had been monitored for up to 9 years for potentially xenotic pig viruses: pig endogenous retrovirus, pig cytomegalovirus, pig lymphotropic herpesvirus, and pig circovirus type 2. No evidence of viral infection was found.

摘要

本研究是对接受猪胰岛异种移植的人类患者进行的长期随访。18名患者接受了长达9年的监测，以检测潜在的异种猪病毒：猪内源性逆转录病毒、猪巨细胞病毒、猪嗜淋巴细胞疱疹病毒和猪圆环病毒2型。未发现病毒感染的证据。

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本文引用的文献

1
Porcine endogenous retroviruses (PERVs) and xenotransplantation: screening for transmission in several clinical trials and in experimental models using non-human primates.猪内源性逆转录病毒（PERVs）与异种移植：在多项临床试验及使用非人灵长类动物的实验模型中筛查传播情况。
Ann Transplant. 2003;8(3):39-48.
2
Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2.用1型猪圆环病毒和2型猪圆环病毒对人细胞系进行的感染研究。
Xenotransplantation. 2004 May;11(3):284-94. doi: 10.1111/j.1399-3089.2004.00134.x.
3
Monitoring for potentially xenozoonotic viruses in New Zealand pigs.监测新西兰猪体内潜在的异种动物源病毒。
J Med Virol. 2004 Feb;72(2):338-44. doi: 10.1002/jmv.10575.
4
Porcine endogenous retroviruses: no infection in patients treated with a bioreactor based on porcine liver cells.猪内源性逆转录病毒：在接受基于猪肝细胞的生物反应器治疗的患者中未发生感染。
J Clin Virol. 2003 Oct;28(2):141-54. doi: 10.1016/s1386-6532(02)00275-5.
5
Clinical extracorporeal hybrid liver support--phase I study with primary porcine liver cells.临床体外混合肝支持——原代猪肝细胞的I期研究
Xenotransplantation. 2003 Sep;10(5):460-9. doi: 10.1034/j.1399-3089.2003.00062.x.
6
Methods for the exclusion of circoviruses and gammaherpesviruses from pigs.从猪群中排除圆环病毒和γ-疱疹病毒的方法。
Xenotransplantation. 2003 Jul;10(4):343-8. doi: 10.1034/j.1399-3089.2003.02048.x.
7
Neutralizing antibodies against conserved domains of p15E of porcine endogenous retroviruses: basis for a vaccine for xenotransplantation?针对猪内源性逆转录病毒p15E保守结构域的中和抗体：异种移植疫苗的基础？
Virology. 2003 Mar 15;307(2):406-13. doi: 10.1016/s0042-6822(02)00140-x.
8
Porcine cytomegalovirus in pigs being bred for xenograft organs: progress towards control.用于异种移植器官培育的猪中的猪巨细胞病毒：控制进展
Xenotransplantation. 2003 Mar;10(2):142-8. doi: 10.1034/j.1399-3089.2003.01128.x.
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Virus safety in xenotransplantation: first exploratory in vivo studies in small laboratory animals and non-human primates.异种移植中的病毒安全性：在小型实验动物和非人灵长类动物中的首次探索性体内研究。
Transpl Immunol. 2002 May;9(2-4):281-8. doi: 10.1016/s0966-3274(02)00039-4.
10
Absence of PERV specific humoral immune response in baboons after transplantation of porcine cells or organs.猪细胞或器官移植后狒狒体内不存在猪内源性逆转录病毒（PERV）特异性体液免疫反应。
Transpl Int. 2002 Jul;15(7):361-8. doi: 10.1007/s00147-002-0428-7. Epub 2002 Jun 22.