一名来自莫桑比克的旅行者出现对奎宁耐药的恶性疟原虫疟疾的基因确诊，随后发生疟疾后神经综合征。
Genetic confirmation of quinine-resistant Plasmodium falciparum malaria followed by postmalaria neurological syndrome in a traveler from Mozambique.
作者信息
Palmieri Fabrizio, Petrosillo Nicola, Paglia Maria Grazia, Conte Aristide, Goletti Delia, Pucillo Leopoldo Paolo, Menegon Michela, Sannella Anna, Severini Carlo, Majori Giancarlo
机构信息
Istituto Nazionale per le Malattie Infettive Lazzo Spallanzani, Rome, Italy.
出版信息
J Clin Microbiol. 2004 Nov;42(11):5424-6. doi: 10.1128/JCM.42.11.5424-5426.2004.
Abstract
A case of quinine-resistant Plasmodium falciparum malaria, followed by a postmalaria neurological syndrome and a recurrence episode, is described. Genetic characterization of the P. falciparum isolate obtained by analysis of msp1 and msp2 amplicons revealed the coexistence of two genotypes causing the first malaria episode and the presence of a unique isolate responsible for the recurrence.
摘要
描述了1例对奎宁耐药的恶性疟原虫疟疾病例，随后出现疟疾后神经综合征和复发发作。通过对msp1和msp2扩增子的分析对获得的恶性疟原虫分离株进行基因特征分析，结果显示导致首次疟疾发作的两种基因型共存，且存在一个导致复发的独特分离株。
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