2007 年从塞内加尔返回的旅行者中出现耐奎宁疟疾。
Quinine-resistant malaria in traveler returning from Senegal, 2007.
机构信息
Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
出版信息
Emerg Infect Dis. 2010 Mar;16(3):546-8. doi: 10.3201/eid1603.091669.
Abstract
We describe clinical and parasitologic features of in vivo and in vitro Plasmodium falciparum resistance to quinine in a nonimmune traveler who returned to France from Senegal in 2007 with severe imported malaria. Clinical quinine failure was associated with a 50% inhibitory concentration of 829 nmol/L. Increased vigilance is required during treatment follow-up.
摘要
我们描述了一位非免疫旅行者在 2007 年从塞内加尔返回法国时患有严重输入性疟疾，体内和体外疟原虫对奎宁的临床和寄生虫学耐药特征。临床奎宁治疗失败与 829 纳摩尔/升的 50%抑制浓度相关。在治疗随访期间需要提高警惕。
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