Abd Ellah Mahmoud Rushdi, Niishimori Kazuhiro, Goryo Masanobu, Okada Keiji, Yasuda Jun
Veterinary Teaching Hospital , Faculty of Agriculture, Iwate University, Morioka, Japan.
J Vet Med Sci. 2004 Oct;66(10):1219-21. doi: 10.1292/jvms.66.1219.
A total of 46 cattle, including 25 as control, 16 with glycogen degeneration and 5 with severe fatty degeneration were studied. Whole blood and liver tissue specimens were used to measure glutathione peroxidase (GSH-Px) and Glucose-6-Phosphate Dehydrogenase (G6PD) activities. The present study determined the value of these parameters in diagnosing glycogen and fatty degeneration in cattle from the point of the status of antioxidation and lipid peroxidation. The results showed a significant decrease in hepatic GSH-Px activity and a significant increase in hepatic G6PD activity in cases of fatty degeneration. On the other hand, there were no significant changes in erythrocytic and hepatic GSH-Px and G6PD activities in cases of glycogen degeneration. The results indicated lipoperoxidation process in the liver tissues increased in cases of fatty degeneration. Therefore, supplying animals suffering from fatty liver with sufficient quantities of nutrient antioxidants may be valuable when treatment is considered.
总共对46头牛进行了研究，其中25头作为对照，16头有糖原变性，5头有严重脂肪变性。使用全血和肝脏组织样本测量谷胱甘肽过氧化物酶（GSH-Px）和葡萄糖-6-磷酸脱氢酶（G6PD）的活性。本研究从抗氧化和脂质过氧化状态的角度确定了这些参数在诊断牛糖原和脂肪变性中的价值。结果显示，在脂肪变性病例中，肝脏GSH-Px活性显著降低，肝脏G6PD活性显著升高。另一方面，在糖原变性病例中，红细胞和肝脏的GSH-Px及G6PD活性没有显著变化。结果表明，在脂肪变性病例中，肝脏组织中的脂质过氧化过程增加。因此，在考虑治疗时，为患脂肪肝的动物提供足够数量的营养抗氧化剂可能是有价值的。
