单克隆抗体在伯氏考克斯氏体主要抗原分析中的应用。
Use of monoclonal antibodies for analyses of Coxiella burnetii major antigens.
作者信息
Hotta Akitoyo, Zhang Guo Quan, Andoh Masako, Yamaguchi Tsuyoshi, Fukushi Hideto, Hirai Katsuya
机构信息
Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
J Vet Med Sci. 2004 Oct;66(10):1289-91. doi: 10.1292/jvms.66.1289.
Monoclonal antibodies (MAbs) to major antigens of Coxiella burnetii were produced. Some of the MAbs to a 62-kDa protein antigen, peptidoglycan protein complex and lipopolysaccharide (LPS) O-chains reacted with other bacteria whereas none of the MAbs to outer membrane proteins and LPS outer-core did. The LPS outer-core and OMPs may be useful antigens for specifically detecting antibodies to C. burnetii.
制备了针对伯氏考克斯氏体主要抗原的单克隆抗体（MAb）。一些针对62 kDa蛋白抗原、肽聚糖蛋白复合物和脂多糖（LPS）O链的单克隆抗体与其他细菌发生反应，而针对外膜蛋白和LPS外核心的单克隆抗体则没有。LPS外核心和外膜蛋白可能是特异性检测伯氏考克斯氏体抗体的有用抗原。
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