Swindells K, Rhodes L E
Photobiology Unit, Dermatology Centre, University of Manchester School of Medicine and Hope Hospital, Manchester, UK.
Photodermatol Photoimmunol Photomed. 2004 Dec;20(6):297-304. doi: 10.1111/j.1600-0781.2004.00121.x.
Ultraviolet radiation (UVR) causes a range of acute and chronic adverse cutaneous effects, in addition to some beneficial effects. In present times, the skin is generally exposed to higher levels of UVR, such that inherent defence mechanisms become overwhelmed. Complications, notably skin malignancies, show a serious rise in incidence. Since many effects of UVR are mediated through generation of reactive oxygen species, antioxidant supplementation provides a strategy to combat their excess generation, and hence reduce the clinical consequences. Human supplementation studies examining the potential of a range of oral agents to protect against UVR-induced skin effects show mixed results; further studies should examine whether certain subgroups of the population may show augmented benefit.
紫外线辐射（UVR）除了会产生一些有益影响外，还会导致一系列急性和慢性不良皮肤效应。目前，皮肤通常暴露于更高水平的紫外线辐射下，以至于其固有的防御机制不堪重负。并发症，尤其是皮肤恶性肿瘤的发病率显著上升。由于紫外线辐射的许多效应是通过活性氧的产生介导的，补充抗氧化剂提供了一种对抗其过量产生的策略，从而减少临床后果。关于一系列口服制剂预防紫外线辐射引起的皮肤效应潜力的人体补充研究结果不一；进一步的研究应探讨某些人群亚组是否可能显示出更大的益处。
