van Asselt Kristel M, Kok Helen S, Pearson Peter L, Dubas Judith S, Peeters Petra H M, Te Velde Egbert R, van Noord Paulus A H
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Fertil Steril. 2004 Nov;82(5):1348-51. doi: 10.1016/j.fertnstert.2004.04.047.
To determine the heritability of age at natural menopause from mother-daughter pairs.
Two-generation families were selected to study heritability of menopausal age.
Subjects were drawn from a population-based study.
PATIENT(S): One hundred sixty-four mother-daughter pairs with a natural menopausal age.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): The heritability of age at natural menopause estimated by a random-effects model.
RESULT(S): A heritability of 44% (95% confidence interval, 36%, 50%) was estimated.
CONCLUSION(S): This study confirms that heritable components largely determine the natural age at menopause. Reasons for the differences between heritability estimates based on sibling pairs and parent-child comparisons are discussed.
通过母女对来确定自然绝经年龄的遗传度。
选择两代家庭来研究绝经年龄的遗传度。
研究对象来自一项基于人群的研究。
164对有自然绝经年龄的母女对。
无。
通过随机效应模型估计自然绝经年龄的遗传度。
估计遗传度为44%（95%置信区间，36%，50%）。
本研究证实遗传因素在很大程度上决定了自然绝经年龄。讨论了基于兄弟姐妹对和亲子比较的遗传度估计存在差异的原因。
