Stefan Raluca-Ioana, Staden Jacobus F van, Bala Camelia, Aboul-Enein Hassan Y
Department of Chemistry, University of Pretoria, 0002 Pretoria, South Africa.
J Pharm Biomed Anal. 2004 Nov 19;36(4):889-92. doi: 10.1016/j.jpba.2004.08.017.
A sequential injection analysis/amperometric biosensor system is proposed for the enantioselective analysis of the S-enantiomer of enalapril, ramipril and pentopril. The amperometric biosensor used as detector in the sequential injection analysis was designed by immobilization of l-amino acid oxidase in carbon paste. The proposed SIA system can be utilized reliably for the enantioanalysis of the S-enantiomer from the raw materials as well as from their pharmaceutical formulations, with a rate of 75 samples per hour and R.S.D. values better than 0.1% (n = 10).
