Arida Hassan, Ahmed Mona, Ali Abdallah
Hot Laboratories Center, Atomic Energy Authority, Cairo 13759, Egypt.
Int J Anal Chem. 2009;2009:954083. doi: 10.1155/2009/954083. Epub 2009 Apr 6.
The fabrication and electrochemical evaluation of two PVC membrane-based Ion-Selective electrodes responsive for ramipril drug have been proposed. The sensitive membranes were prepared using ramipril-phosphomolibdate and ramipril-tetraphenylborate ion-pair complexes as electroactive sensing materials in plasticized PVC support. The electrodes based on these materials provide near-Nernestian response (sensitivity of 53 +/- 0.5-54 +/- 0.5 mV/concentration decade) covering the concentration range of 1.0 x 10(-2)-1.0 x 10(-5) mol L(-1) with a detection limit of 3.0 x 10(-6)-4.0 x 10(-6) mol L(-1). The suggested electrodes have been successfully used in the determination of ramipril drug in some pharmaceutical formulations using direct potentiometry with average recovery of >96% and mean standard deviation of <3% (n = 5).
本文提出了两种基于聚氯乙烯（PVC）膜的、对雷米普利药物有响应的离子选择性电极的制备及其电化学评估。以雷米普利 - 磷钼酸盐和雷米普利 - 四苯基硼酸盐离子对配合物作为电活性传感材料，在增塑的PVC载体中制备了敏感膜。基于这些材料的电极呈现近能斯特响应（灵敏度为53±0.5 - 54±0.5 mV/浓度 decade），浓度范围覆盖1.0×10⁻² - 1.0×10⁻⁵ mol L⁻¹，检测限为3.0×10⁻⁶ - 4.0×10⁻⁶ mol L⁻¹。所建议的电极已成功用于通过直接电位法测定某些药物制剂中的雷米普利药物，平均回收率>96%，平均标准偏差<3%（n = 5）。
