Song Shu-Zhen, Liu Hong-Ying, Shen Hong, Yuan Bin, Dong Zhen-Nan, Jia Xing-Wang, Tian Ya-Ping
Department of Clinical Biochemistry, PLA General Hospital and Postgraduate Medical School, Beijing 100853, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2004 Nov;16(11):664-6.
To identify blood chemistry changes in coronavirus of severe acute respiratory syndrome (SARS).
Biochemical changes in SARS patients were summarized and compared with other viral pneumonias. Serum total protein (TP), albumin (Alb), total cholesterol (TC), triglyceride (TG), calcium (Ca), ferrum (Fe), lactate dehydrogenase (LDH), creatine kinase (CK), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) between SARS and other viral pneumonias were examined by Roche Diagnostics assay, HITACHI7600 automatic analyzer. Clinically confirmed SARS patients, patients with other viral pneumonias, and healthy controls were included in the study.
Compared with healthy person, the levels of serum TC, Fe, Ca, Alb were significantly lowered (P<0.05 or P<0.01), while the activity of LDH, CK, ALT, AST were elevated, the increase of CK and the decrease of Fe were the most significant (P<0.05 or P<0.01), the changes of TP and TG were not obvious. In the other viral pneumonias patients, ALT, AST, LDH were elevated slightly than those of healthy person, while Fe, Ca, Alb, TC, CK were a little reduced, but there was no significant difference between the two groups. In convalescent stage, all the tests were returned to normal ranges except ALT, AST were still elevated in SARS patients.
The changes in serum biochemistry are more marked in SARS patients compared with patients suffering from other viral pneumonias, the decrease of Fe as well as the inhibition of TC may be caused by the treatment of anti-virus.
确定严重急性呼吸综合征（SARS）冠状病毒感染时的血液生化变化。
总结SARS患者的生化变化，并与其他病毒性肺炎进行比较。采用罗氏诊断检测法、日立7600自动分析仪检测SARS患者与其他病毒性肺炎患者血清总蛋白（TP）、白蛋白（Alb）、总胆固醇（TC）、甘油三酯（TG）、钙（Ca）、铁（Fe）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平。研究纳入临床确诊的SARS患者、其他病毒性肺炎患者和健康对照者。
与健康人相比，SARS患者血清TC、Fe、Ca、Alb水平显著降低（P<0.05或P<0.01），而LDH、CK、ALT、AST活性升高，CK升高及Fe降低最为显著（P<0.05或P<0.01），TP和TG变化不明显。其他病毒性肺炎患者ALT、AST、LDH较健康人略有升高，而Fe、Ca、Alb、TC、CK略有降低，但两组间差异无统计学意义。在恢复期，除SARS患者ALT、AST仍升高外，其余各项检测均恢复至正常范围。
与其他病毒性肺炎患者相比，SARS患者血清生化变化更为明显，Fe降低及TC受抑制可能与抗病毒治疗有关。
