Lladó I, Pons A, Palou A
Laboratori de Bioquímica i Biologia Molecular, Department de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain.
J Nutr Biochem. 1999 Oct;10(10):609-14. doi: 10.1016/s0955-2863(99)00050-9.
The aim of the present study was to evaluate the effects of 24 hours of starvation on lipoprotein lipase (LPL) activity in various depots of white and brown adipose tissues in control rats and in rats with two different degrees of overweight, both induced by dietary treatment. In control rats, no changes in LPL immunoreactive mass were observed in either white or brown adipose tissues after fasting, whereas the effects of food deprivation on enzyme activity were opposite in white versus brown adipose tissues. The LPL activity response to fasting was impaired by obesity: White adipose depots of cafeteria obese rats showed a lower ability to downregulate LPL during fasting and the increased LPL activity induced by fasting in brown adipose depots was less intense in the obese rats compared with control animals. When the degree of overweight was reduced, the differences between obese and control rats were also attenuated.
本研究的目的是评估24小时饥饿对正常大鼠以及由饮食诱导产生两种不同超重程度的大鼠白色和棕色脂肪组织各储存部位脂蛋白脂肪酶（LPL）活性的影响。在正常大鼠中，禁食后白色或棕色脂肪组织中LPL免疫反应性物质均未观察到变化，而禁食对酶活性的影响在白色和棕色脂肪组织中相反。肥胖会削弱LPL活性对禁食的反应：与对照动物相比，食用自助食堂食物导致肥胖的大鼠白色脂肪储存部位在禁食期间下调LPL的能力较低，且棕色脂肪储存部位由禁食诱导的LPL活性增加在肥胖大鼠中不那么强烈。当超重程度降低时，肥胖大鼠与正常大鼠之间的差异也会减弱。
