Rouse Andrew R, Kano Angelique, Udovich Joshua A, Kroto Shona M, Gmitro Arthur F
Optical Science Center and the Department of Radiology, University of Arizona, Tucson, Arizona 85724, USA.
Appl Opt. 2004 Nov 1;43(31):5763-71. doi: 10.1364/ao.43.005763.
The fluorescence confocal microendoscope provides high-resolution, in vivo imaging of cellular pathology during optical biopsy. The confocal microendoscope employs a flexible fiber-optic catheter coupled to a custom-built slit-scan confocal microscope. The catheter consists of a fiber-optic imaging bundle linked to a miniature objective and focus assembly. The 3-mm-diameter catheter may be used on its own or routed though the instrument channel of a commercial endoscope, adding microscopic imaging capability to conventional endoscopy. The design and performance of the miniature objective and focus assembly are discussed. Primary applications of the system include diagnosis of disease in the gastrointestinal tract and female reproductive system.
荧光共聚焦微型内窥镜可在光学活检过程中提供细胞病理学的高分辨率体内成像。共聚焦微型内窥镜采用与定制的狭缝扫描共聚焦显微镜相连的柔性光纤导管。该导管由连接到微型物镜和聚焦组件的光纤成像束组成。直径3毫米的导管可以单独使用，也可以通过商用内窥镜的器械通道插入，从而为传统内窥镜检查增添微观成像能力。文中讨论了微型物镜和聚焦组件的设计与性能。该系统的主要应用包括胃肠道和女性生殖系统疾病的诊断。
