Naldi L, Gallus S, Tavani A, Imberti G L, La Vecchia C
Centro Studi GISED, Ospedali Riuniti di Bergamo, Bergamo, Italy.
Eur J Cancer Prev. 2004 Dec;13(6):503-8. doi: 10.1097/00008469-200412000-00007.
Limited information is available on the association between the risk of cutaneous malignant melanoma (CMM) and dietary factors. The issue was investigated using data from a case-control study conducted in Italy between 1992 and 1994, including 542 patients with incident, histologically confirmed CMM and 538 controls, admitted to the same hospitals as cases for non-dermatologic and non-neoplastic diseases. We found a significant inverse association between vitamin A intake and CMM risk. The multivariate odds ratio, after allowance for phenotypic characteristics and history of sunburns, for the highest, compared with the lowest, quartile of intake was 0.71 (95% confidence interval (CI) 0.50-1.02) for beta-carotene, 0.57 (95% CI 0.39-0.83) for retinol, and 0.51 (95% CI 0.35-0.74) for total vitamin A. We found no appreciable association of CMM risk with selected food items, including fish, meat, vegetables, fruit, dairy products, wholemeal bread, alcohol, coffee and tea drinking. Consumption of tea appeared to have a protective effect on CMM risk. The relations with measures of dietary vitamin A are, however, moderate compared with the associations between phenotypic characteristics, sun exposure and number of naevi and CMM risk.
关于皮肤恶性黑色素瘤（CMM）风险与饮食因素之间的关联，目前可用信息有限。利用1992年至1994年在意大利进行的一项病例对照研究的数据对该问题进行了调查，该研究包括542例组织学确诊的新发CMM患者和538名对照，这些对照因非皮肤病和非肿瘤性疾病与病例入住同一医院。我们发现维生素A摄入量与CMM风险之间存在显著的负相关。在考虑了表型特征和晒伤史后，摄入量最高四分位数与最低四分位数相比，β-胡萝卜素的多变量优势比为0.71（95%置信区间（CI）0.50 - 1.02），视黄醇为0.57（95%CI 0.39 - 0.83），总维生素A为0.51（95%CI 0.35 - 0.74）。我们发现CMM风险与所选食物项目（包括鱼、肉、蔬菜、水果、乳制品、全麦面包、酒精、咖啡和茶的饮用）之间没有明显关联。饮茶似乎对CMM风险有保护作用。然而，与表型特征、阳光暴露和痣的数量与CMM风险之间的关联相比，饮食中维生素A的相关关系较为适中。
