严重急性呼吸综合征冠状病毒刺突蛋白四级组装的预测
Prediction of quaternary assembly of SARS coronavirus peplomer.
作者信息
Bernini Andrea, Spiga Ottavia, Ciutti Arianna, Chiellini Stefano, Bracci Luisa, Yan Xiyun, Zheng Bojian, Huang Jiandong, He Ming-Liang, Song Huai-Dong, Hao Pei, Zhao Guoping, Niccolai Neri
机构信息
Department of Molecular Biology, Biomolecular Structure Research Center, University of Siena, I-53100 Siena, Italy.
出版信息
Biochem Biophys Res Commun. 2004 Dec 24;325(4):1210-4. doi: 10.1016/j.bbrc.2004.10.156.
Abstract
The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections.
摘要
导致严重急性呼吸综合征（SARS）的冠状病毒刺突蛋白S1和S2结构域的三级结构最近已被预测出来。本文提出了一种SARS冠状病毒纤突的分子组装体，它能够解释现有的功能数据。S1和S2之间的相互作用似乎通过两个结构域中均存在的一个由芳香族侧链构成的大型疏水网络得以稳定。这一特征在所有冠状病毒中都很常见，这表明可能存在预防冠状病毒相关感染的药物潜在靶点。
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