非特异性间质性肺炎：一种真实的临床实体？

Nonspecific interstitial pneumonia: a real clinical entity?

作者信息

Nagai Sonoko, Handa Tomohiro, Tabuena Rollin, Kitaichi Masanori, Izumi Takateru

机构信息

Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University, 606-8507, Kyoto, Japan.

出版信息

Clin Chest Med. 2004 Dec;25(4):705-15, vi. doi: 10.1016/j.ccm.2004.04.009.

DOI:10.1016/j.ccm.2004.04.009

PMID:15564016

Abstract

Based on the current multidisciplinary classification of idiopathic interstitial pneumonia (IIP) organized by ATS/ERS, nonspecific interstitial pneumonia (NSIP) is considered as one type of IIP. An incidence of idiopathic NSIP is relatively small and possesses clinical features that are different than idiopathic pulmonary fibrosis (IPF) and usual interstitial pneumonia (UIP). Because there is little evidence of a long-term prognosis in patients with NSIP, some of them have an unfavorable prognosis similar to IPF/UIP. We review the significance of prognostic factors that have been reported in patients with IPF/UIP by applying them to patients with NSIP. The association with collagen vascular diseases focuses on etiologic background. Finally, the article discusses whether NSIP could be an early lesion of UIP based on the reported evidence and our own professional experiences.

摘要

基于美国胸科学会（ATS）/欧洲呼吸学会（ERS）组织的特发性间质性肺炎（IIP）当前多学科分类，非特异性间质性肺炎（NSIP）被视为IIP的一种类型。特发性NSIP的发病率相对较低，具有与特发性肺纤维化（IPF）和寻常型间质性肺炎（UIP）不同的临床特征。由于NSIP患者长期预后的证据较少，其中一些患者的预后不良，类似于IPF/UIP。我们通过将已报道的IPF/UIP患者预后因素应用于NSIP患者，来回顾其意义。与胶原血管疾病的关联集中在病因背景方面。最后，本文根据已报道的证据和我们自己的专业经验，讨论NSIP是否可能是UIP的早期病变。