Messer Shawn A, Kirby Jeffrey T, Sader Helio S, Fritsche Thomas R, Jones Ronald N
The JONES Group/JMI Laboratories, Inc., 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.
J Antimicrob Chemother. 2004 Dec;54(6):1051-6. doi: 10.1093/jac/dkh504. Epub 2004 Nov 25.
This longitudinal study evaluated the in vitro activity of anidulafungin against 880 clinical yeast isolates and 68 mould isolates from 64 medical centres in North America, Latin America and Europe.
MICs of anidulafungin, amphotericin B, 5-fluorocytosine, fluconazole, itraconazole, ketoconazole and voriconazole were determined using reference method (M27-A2) guidelines. The M38-A reference method was used for the filamentous fungi, including determination of minimum effective concentrations (MECs) of anidulafungin.
Anidulafungin was more active when compared with fluconazole and itraconazole for Candida albicans (MIC(90), 0.06 mg/L), Candida tropicalis (MIC(90), 0.06 mg/L), Candida glabrata (MIC(90), 0.12 mg/L), Candida krusei (MIC(90), 0.06 mg/L) and Candida lusitaniae (MIC(90), 1 mg/L) as well as the less-often encountered yeast species. Anidulafungin was less active against Candida parapsilosis, Candida guilliermondii and Candida famata (MIC(50), 1-2 mg/L). Anidulafungin also exhibited excellent activity against all Aspergillus spp. (MEC(90), < or =0.03 mg/L). Anidulafungin was also evaluated comparing two end point reading criteria and two incubation intervals. Data indicate that longer incubation periods do not significantly influence overall MIC ranges. These international surveillance results for anidulafungin confirm the activity observed in studies of smaller numbers of isolates.
这项纵向研究评估了阿尼芬净对来自北美、拉丁美洲和欧洲64个医疗中心的880株临床酵母分离株和68株霉菌分离株的体外活性。
采用参考方法（M27 - A2）指南测定阿尼芬净、两性霉素B、5-氟胞嘧啶、氟康唑、伊曲康唑、酮康唑和伏立康唑的最低抑菌浓度（MIC）。丝状真菌采用M38 - A参考方法，包括测定阿尼芬净的最低有效浓度（MEC）。
与氟康唑和伊曲康唑相比，阿尼芬净对白色念珠菌（MIC90，0.06mg/L）、热带念珠菌（MIC90，0.06mg/L）、光滑念珠菌（MIC90，0.12mg/L）、克柔念珠菌（MIC90，0.06mg/L）和葡萄牙念珠菌（MIC90，1mg/L）以及较少见的酵母菌种活性更强。阿尼芬净对近平滑念珠菌、季也蒙念珠菌和法塔念珠菌活性较弱（MIC50，1 - 2mg/L）。阿尼芬净对所有曲霉属菌种也表现出优异活性（MEC90，≤0.03mg/L）。还比较了阿尼芬净的两种终点读数标准和两种孵育间隔。数据表明较长的孵育期对总体MIC范围没有显著影响。这些阿尼芬净的国际监测结果证实了在较少数量分离株研究中观察到的活性。
