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2
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本文引用的文献

1
Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains.全球范围内念珠菌菌株的 fks1 热点 1 突变低流行率。
Antimicrob Agents Chemother. 2010 Jun;54(6):2655-9. doi: 10.1128/AAC.01711-09. Epub 2010 Apr 5.
2
Echinocandin susceptibility testing of Candida species: comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, disk diffusion, and agar dilution methods with RPMI and isosensitest media.棘白菌素类药物敏感性检测方法：比较 EUCAST EDef 7.1、CLSI M27-A3、Etest、纸片扩散法和琼脂稀释法与 RPMI 和 IsoSensitest 培养基的结果。
Antimicrob Agents Chemother. 2010 Jan;54(1):426-39. doi: 10.1128/AAC.01256-09. Epub 2009 Nov 2.
3
Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint.光滑念珠菌FKS1和FKS2突变对棘白菌素敏感性及1,3-β-D-葡聚糖合酶动力学的影响：对现有药敏折点的意义
Antimicrob Agents Chemother. 2009 Sep;53(9):3690-9. doi: 10.1128/AAC.00443-09. Epub 2009 Jun 22.
4
Consensus statement on the management of invasive candidiasis in Intensive Care Units in the Asia-Pacific Region.亚太地区重症监护病房侵袭性念珠菌病管理的共识声明。
Int J Antimicrob Agents. 2009 Sep;34(3):205-9. doi: 10.1016/j.ijantimicag.2009.03.014. Epub 2009 May 5.
5
Activity of contemporary antifungal agents, including the novel echinocandin anidulafungin, tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: report from the SENTRY Antimicrobial Surveillance Program (2006 to 2007).当代抗真菌药物（包括新型棘白菌素阿尼芬净）对念珠菌属、隐球菌属和曲霉属的活性：哨兵抗菌监测计划（2006年至2007年）报告
J Clin Microbiol. 2009 Jun;47(6):1942-6. doi: 10.1128/JCM.02434-08. Epub 2009 Apr 22.
6
Mutations in the fks1 gene in Candida albicans, C. tropicalis, and C. krusei correlate with elevated caspofungin MICs uncovered in AM3 medium using the method of the European Committee on Antibiotic Susceptibility Testing.白色念珠菌、热带念珠菌和克鲁斯念珠菌中fks1基因的突变，与采用欧洲抗生素敏感性试验委员会的方法在AM3培养基中发现的卡泊芬净最低抑菌浓度升高相关。
Antimicrob Agents Chemother. 2008 Sep;52(9):3092-8. doi: 10.1128/AAC.00088-08. Epub 2008 Jun 30.
7
Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints.针对念珠菌属对卡泊芬净、阿尼芬净和米卡芬净的药敏试验，其最低抑菌浓度（MIC）与结果的相关性：分析及MIC解释性折点建议
J Clin Microbiol. 2008 Aug;46(8):2620-9. doi: 10.1128/JCM.00566-08. Epub 2008 Jun 25.
8
Quality control and reference guidelines for CLSI broth microdilution method (M38-A document) for susceptibility testing of anidulafungin against molds.针对阿尼芬净对霉菌药敏试验的CLSI肉汤微量稀释法（M38-A文件）的质量控制和参考指南。
J Clin Microbiol. 2007 Jul;45(7):2180-2. doi: 10.1128/JCM.00399-07. Epub 2007 May 2.
9
Acquired resistance to echinocandins in Candida albicans: case report and review.白色念珠菌对棘白菌素的获得性耐药：病例报告及文献复习
J Antimicrob Chemother. 2007 Jun;59(6):1076-83. doi: 10.1093/jac/dkm095. Epub 2007 Apr 27.
10
New agents for the treatment of fungal infections: clinical efficacy and gaps in coverage.治疗真菌感染的新型药物：临床疗效与覆盖范围的差距
Clin Infect Dis. 2006 Oct 15;43(8):1060-8. doi: 10.1086/507891. Epub 2006 Sep 8.

比较了棘白菌素类药物（阿尼芬净）与其他 9 种抗真菌药物对念珠菌属、隐球菌属和曲霉菌属的体外抗菌活性：全球 SENTRY 抗菌药物监测计划（2008 年）的结果。

Potency of anidulafungin compared to nine other antifungal agents tested against Candida spp., Cryptococcus spp., and Aspergillus spp.: results from the global SENTRY Antimicrobial Surveillance Program (2008).

机构信息

JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317, USA.

出版信息

J Clin Microbiol. 2010 Aug;48(8):2984-7. doi: 10.1128/JCM.00328-10. Epub 2010 Jun 9.

DOI:10.1128/JCM.00328-10
PMID:20534798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2916586/
Abstract

The SENTRY Antimicrobial Surveillance Program regularly monitors global susceptibility rates for a spectrum of both novel and established antifungal agents. Anidulafungin and the other echinocandins displayed sustained, excellent activity against Candida spp. and Aspergillus fumigatus, with >or=98% of MIC results at <or=2 microg/ml. Six yeast isolates (all Candida glabrata) showing caspofungin MIC values of >or=0.5 microg/ml were further analyzed for potential fks hot spot (HS) mutations; three isolates had confirmed mutations in the fks1 HS1 region (S645P), and three exhibited mutations in the fks2 HS1 region (S645F and S645P).

摘要

SENTRY 抗菌监测计划定期监测各种新型和已建立的抗真菌药物的全球敏感性率。阿尼达fungin 和其他棘白菌素对念珠菌属和烟曲霉表现出持续、优异的活性，MIC 结果<或=2μg/ml 时>或=98%。6 株酵母分离株（均为光滑念珠菌）的卡泊芬净 MIC 值>或=0.5μg/ml，进一步分析潜在的 fks 热点（HS）突变；3 株分离株在 fks1 HS1 区域（S645P）有确认的突变，3 株在 fks2 HS1 区域（S645F 和 S645P）有突变。