Giannoulis E, Economopoulos T, Mandraveli K, Giannoulis K, Nikolaides C, Zervou E, Papageorgiou E, Zoulas D, Tourkantonis A, Giannopoulos G, Fountzilas G
AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Acta Haematol. 2004;112(4):189-93. doi: 10.1159/000081270.
Our aim was to investigate the association between chronic hepatitis C virus (HCV) infection and B cell non-Hodgkin lymphoma (NHL) in the Greek population. We studied 120 patients (70 men and 50 women, mean age 59 years) diagnosed with NHL. One hundred and eight had B cell NHL (90%) and 12 had T cell NHL (10%). The presence of anti-HCV antibodies in patients and controls was investigated using the monoclonal enzymatic immunoassay (MEIA) method. The detection of HCV RNA and hepatitis G virus (HGV) RNA in patients with B cell NHL and anti-HCV-positive controls was performed using an RT-PCR technique. Anti-HCV antibodies were present in only 2 of the 108 patients with B cell NHL (1.9%), while the prevalence of HCV infection in the healthy population was 0.6%, and in patients with various solid tumors treated with chemotherapy, it was 0.99%. Ten of the 108 B cell NHL patients (9.26%) were diagnosed as HGV RNA positive, while the prevalence of HGV infection in 285 Greek blood donors was 0.7%. Our findings do not confirm a strong association between HCV infection and B cell NHL for Greek patients. The increased prevalence of HGV infection detected in patients with NHL could imply the potential participation of HGV in the pathogenesis of NHL.
我们的目的是调查希腊人群中慢性丙型肝炎病毒（HCV）感染与B细胞非霍奇金淋巴瘤（NHL）之间的关联。我们研究了120例被诊断为NHL的患者（70名男性和50名女性，平均年龄59岁）。其中108例为B细胞NHL（90%），12例为T细胞NHL（10%）。采用单克隆酶免疫测定（MEIA）方法调查患者和对照中抗HCV抗体的存在情况。使用逆转录聚合酶链反应（RT-PCR）技术检测B细胞NHL患者和抗HCV阳性对照中的HCV RNA和庚型肝炎病毒（HGV）RNA。在108例B细胞NHL患者中，仅有2例（1.9%）存在抗HCV抗体，而健康人群中HCV感染的患病率为0.6%，接受化疗的各种实体瘤患者中HCV感染的患病率为0.99%。108例B细胞NHL患者中有10例（9.26%）被诊断为HGV RNA阳性，而285名希腊献血者中HGV感染的患病率为0.7%。我们的研究结果并未证实希腊患者中HCV感染与B细胞NHL之间存在强关联。在NHL患者中检测到的HGV感染患病率增加可能意味着HGV在NHL发病机制中具有潜在作用。
