Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
Department of Internal Medicine, Iowa City Veterans Affairs Medical Center, University of Iowa, Iowa City, Iowa.
Cancer Res. 2014 Oct 1;74(19):5553-60. doi: 10.1158/0008-5472.CAN-14-0209. Epub 2014 Aug 12.
Some retrospective studies suggest an association between infection with GB virus-C (GBV-C) and non-Hodgkin lymphoma (NHL). We evaluated this association prospectively in a nested case-control study within the U.S. Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Cases (N = 658) and controls (N = 1,316) were individually matched by age, sex, race/ethnicity, timing of study entry, and sample selection. Prediagnostic PLCO serum samples were tested for GBV-C RNA (as a measure of active infection) and E2 antibody (active or resolved infection). Logistic regression was used to estimate odds ratios (OR) for the association between GBV-C and NHL overall and NHL subtypes. Twelve cases (1.8%) and seven controls (0.5%) were GBV-C RNA-positive. GBV-C RNA positivity was associated with NHL overall [OR, 3.43; 95% confidence interval (CI), 1.35-8.71] and, based on small numbers, diffuse large B-cell lymphoma (OR, 5.31; 95% CI, 1.54-18.36). The association with NHL persisted when the interval between testing and selection was greater than 4 years (OR, 6.00; 95% CI, 1.21-29.73). In contrast, E2 antibody positivity was not associated with NHL risk (OR, 1.08; 95% CI, 0.74-1.58). Our study demonstrates that GBV-C infection precedes development of NHL. GBV-C infection may play an etiologic role in a small proportion of NHL cases, perhaps by causing chronic immune stimulation or impaired immunosurveillance.
一些回顾性研究表明，庚型肝炎病毒（GB 病毒-C，GBV-C）感染与非霍奇金淋巴瘤（NHL）之间存在关联。我们在美国前列腺癌、肺癌、结直肠癌和卵巢癌（PLCO）筛查试验中进行了一项巢式病例对照研究，前瞻性地评估了这种关联。病例（N=658）和对照（N=1316）按年龄、性别、种族/民族、研究入组时间和样本选择进行个体匹配。使用 PLCO 术前血清样本检测 GBV-C RNA（作为活动性感染的衡量指标）和 E2 抗体（活动性或已解决的感染）。使用逻辑回归估计 GBV-C 与 NHL 总体和 NHL 亚型之间关联的比值比（OR）。12 例病例（1.8%）和 7 例对照（0.5%）为 GBV-C RNA 阳性。GBV-C RNA 阳性与 NHL 总体相关[OR，3.43；95%置信区间（CI），1.35-8.71]，且基于小样本量，弥漫性大 B 细胞淋巴瘤的相关性更强[OR，5.31；95% CI，1.54-18.36]。当检测与选择之间的间隔大于 4 年时，与 NHL 的关联仍然存在[OR，6.00；95% CI，1.21-29.73]。相比之下，E2 抗体阳性与 NHL 风险无关[OR，1.08；95% CI，0.74-1.58]。本研究表明，GBV-C 感染先于 NHL 的发生。GBV-C 感染可能在一小部分 NHL 病例中发挥病因作用，其机制可能是导致慢性免疫刺激或免疫监视受损。
