Fukuyama Yoshiyasu, Minoshima Yuka, Kishimoto Yoshiko, Chen Ih-Sheng, Takahashi Hironobu, Esumi Tomoyuki
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8514, Japan.
J Nat Prod. 2004 Nov;67(11):1833-8. doi: 10.1021/np040138l.
Four new iridoids glucosides (1-4) and seven new iridoid aglycons (5-11) bearing (E)- or (Z)-p-coumaroyl groups were isolated from a methanol extract of the dried leaves of Viburnum luzonicum collected in Kaoshiung, Taiwan. The structures of the new compounds, named luzonoside A (1), luzonoside B (2), luzonoside C (3), luzonoside D (4), luzonoid A (5), luzonoid B (6), luzonoid C (7), luzonoid D (8), luzonoid E (9), luzonoid F (10), and luzonoid G (11), were elucidated by analysis of spectroscopic data and comparison with values for previously known analogues. Among the iridoids isolated in the present study, glucosides 1 and 2, and their aglycons 5-9, exhibited moderate inhibitory activity against HeLa S3 cancer cells, whereas 3 and 4 showed no cytotoxicity even at 100 microM.
从台湾高雄采集的吕宋荚蒾干燥叶的甲醇提取物中，分离得到了4种新的环烯醚萜苷（1 - 4）和7种带有（E）-或（Z）-对香豆酰基的新环烯醚萜苷元（5 - 11）。通过光谱数据分析并与先前已知类似物的值进行比较，阐明了新化合物的结构，它们分别命名为吕宋苷A（1）、吕宋苷B（2）、吕宋苷C（3）、吕宋苷D（4）、吕宋萜A（5）、吕宋萜B（6）、吕宋萜C（7）、吕宋萜D（8）、吕宋萜E（9）、吕宋萜F（10）和吕宋萜G（11）。在本研究分离得到的环烯醚萜中，苷1和2及其苷元5 - 9对HeLa S3癌细胞表现出中等抑制活性，而3和4即使在100微摩尔浓度下也没有细胞毒性。
