Vickrey B G, Hays R D, Graber J, Rausch R, Engel J, Brook R H
Department of Neurology, University of California, Los Angeles 90024-1769.
Med Care. 1992 Apr;30(4):299-319. doi: 10.1097/00005650-199204000-00002.
The goals of surgery in treating intractable epilepsy are to eliminate seizures and improve quality of life. This report describes the development of the Epilepsy Surgery Inventory (ESI)-55, a 55-item measure of health-related quality of life for epilepsy patients. The ESI-55 includes the following scales (number of items in parentheses): health perceptions (9), energy/fatigue (4), overall quality of life (2), social function (2), emotional well-being (5), cognitive function (5), physical function (10), pain (2), and three separate scales of role limitations due to emotional, physical, or memory problems (5 items each). Also included is one change in health item. The ESI-55 was completed by 89% of 224 adults who had undergone a protocol evaluation for epilepsy surgery since 1974. Alpha internal consistency reliability coefficients ranged from 0.76 to 0.88 except for social function (alpha = 0.68). Multitrait scaling analyses supported item discrimination across scales. Factor analysis confirmed previously identified mental and physical health factors, and yielded a third factor defined by cognitive function and role limitations scales. Construct validity was supported by correlations of the ESI-55 with a mood profile instrument. Analysis of ESI-55 scale scores by seizure classification showed that the 44 patients who were seizure-free following surgery scored higher than did 55 patients who continued to have seizures (P less than 0.05 for all comparisons); 43 patients having seizures without loss of consciousness scored in between. Results of this study indicate that the ESI-55 is reliable, valid, and sensitive to differences in seizure status.
手术治疗难治性癫痫的目标是消除癫痫发作并提高生活质量。本报告描述了癫痫手术量表（ESI）-55的开发过程，这是一种针对癫痫患者与健康相关生活质量的55项测量工具。ESI-55包括以下量表（括号内为项目数量）：健康认知（9项）、精力/疲劳（4项）、总体生活质量（2项）、社会功能（2项）、情绪健康（5项）、认知功能（5项）、身体功能（10项）、疼痛（2项），以及因情绪、身体或记忆问题导致的角色限制的三个单独量表（各5项）。还包括一项健康状况变化项目。自1974年以来，224名接受癫痫手术方案评估的成年人中有89%完成了ESI-55量表。除社会功能量表（α = 0.68）外，α内部一致性信度系数在0.76至0.88之间。多特质量表分析支持各量表之间的项目区分度。因素分析证实了先前确定的心理和身体健康因素，并产生了一个由认知功能和角色限制量表定义的第三个因素。ESI-55与情绪状况测量工具的相关性支持了其结构效度。按癫痫分类对ESI-55量表得分进行分析表明，术后无癫痫发作的44名患者得分高于仍有癫痫发作的55名患者（所有比较P均小于0.05）；43名有癫痫发作但无意识丧失的患者得分介于两者之间。本研究结果表明，ESI-55可靠、有效，且对癫痫发作状态的差异敏感。
