Gil Lizette, Martínez Gregorio, Tápanes Rolando, Castro Osvaldo, González Daniel, Bernardo Lidice, Vázquez Susana, Kourí Gustavo, Guzmán María G
Department of Clinical Pharmacology, Hospital/Institute of Tropical Medicine Pedro Kourí, Marianao 13, Havana City, Havana, Cuba.
Am J Trop Med Hyg. 2004 Nov;71(5):652-7.
An association between viral diseases and increased oxidative stress has been suggested. The time course of serum levels of total antioxidant status (TAS), peroxidation potential (PP), glutathione (GSH), lipid peroxidation measured as hydroperoxides, and malondyaldehyde and 4-hydroxyalkenals (MDA + 4-HDA), as well as antioxidant enzymatic activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx), were measured in 22 serologically confirmed dengue patients. Most of the patients had dengue fever and three of them had dengue hemorrhagic fever. The redox parameters were compared with those of age- and sex- matched controls. No significant difference was observed for levels of GSH and TAS between patients and controls. Levels of PP, MDA + 4-HDA, and SOD were significantly higher. Levels of GPx and total hydroperoxides were significantly lower in patients in comparison with controls. These findings suggest that the alteration in redox status could result of increased oxidative stress and it may play a role in the pathogenesis of the disease.
病毒疾病与氧化应激增加之间的关联已被提出。在22例血清学确诊的登革热患者中，测量了总抗氧化状态（TAS）、过氧化潜能（PP）、谷胱甘肽（GSH）、以氢过氧化物衡量的脂质过氧化、丙二醛和4-羟基烯醛（MDA + 4-HDA）的血清水平随时间的变化过程，以及超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的抗氧化酶活性。大多数患者患有登革热，其中3例患有登革出血热。将氧化还原参数与年龄和性别匹配的对照组进行比较。患者和对照组之间GSH和TAS水平未观察到显著差异。PP、MDA + 4-HDA和SOD水平显著更高。与对照组相比，患者的GPx水平和总氢过氧化物水平显著更低。这些发现表明，氧化还原状态的改变可能是氧化应激增加的结果，并且它可能在疾病的发病机制中起作用。
