Preuss Ralf, Koch Holger Martin, Wilhelm Michael, Pischetsrieder Monika, Angerer Jürgen
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen-Nuremberg, Erlangen, Germany.
Int J Hyg Environ Health. 2004 Oct;207(5):441-5. doi: 10.1078/1438-4639-00313.
Concentrations of 1- and 2-naphthol were measured in urine of 72 adults and 35 young children from Germany to assess the internal exposure to naphthalene of the general population. Naphthols could be detected in more than 90% of the urine samples. Levels of naphthols (sum of 1- and 2-naphthol) were 4-fold higher in smokers (median: 37.6 microg/g creatinine) compared to non-smoking adults (8.2 microg/g creatinine). On a creatinine basis young children had slightly lower naphthol levels in urine compared with adults (7.5 microg/g creatinine). Preliminary reference values for the sum of 1- and 2- naphthol in urine as means of the 95th percentile are proposed: 41.2 microg/g creatinine (non-smoking adults) and 23.5 microg/g creatinine (young children). It is concluded that 1- and 2-naphthol levels in urine are suitable for human biomonitoring of the naphthalene exposure in environmental medicine.
为评估普通人群萘的体内暴露情况，对来自德国的72名成年人和35名儿童的尿液中1-萘酚和2-萘酚的浓度进行了测量。超过90%的尿液样本中可检测到萘酚。吸烟者尿液中萘酚（1-萘酚和2-萘酚之和）水平（中位数：37.6微克/克肌酐）是非吸烟成年人（8.2微克/克肌酐）的4倍。以肌酐计，儿童尿液中萘酚水平略低于成年人（7.5微克/克肌酐）。提出了以第95百分位数均值表示的尿液中1-萘酚和2-萘酚之和的初步参考值：41.2微克/克肌酐（非吸烟成年人）和23.5微克/克肌酐（儿童）。得出结论，尿液中1-萘酚和2-萘酚水平适用于环境医学中萘暴露的人体生物监测。
