Yoshikawa M, Nakamura S, Ohno S
Department of Ophthalmology, Yokohama City University School of Medicine, Japan.
Nippon Ganka Gakkai Zasshi. 1992 Feb;96(2):271-5.
The author experienced a 34-year-old male case of acute iridocyclitis with fibrinous exudates accompanied by ankylosing spondylitis with negative HLA-B27. Who was diagnosed definite ankylosing spondylitis by the New York criteria. The cause of ankylosing spondylitis was postulated to be a cross reaction between HLA-B27 and a certain Gram-negative bacillus. However, our case with negative HLA-B27 suggested the causes could comprise multiple factors in addition to HLA-B27. Since the clinical picture of iridocyclitis observed in our case showed no difference with those of HLA-B27 positive cases, iridocyclitis associated with ankylosing spondylitis is considered to be the same entity regardless of HLA-B27 being present or not.
作者遇到一例34岁男性急性虹膜睫状体炎患者，伴有纤维蛋白渗出物，同时患有强直性脊柱炎，HLA - B27阴性。该患者根据纽约标准被诊断为确诊强直性脊柱炎。强直性脊柱炎的病因被推测为HLA - B27与某种革兰氏阴性杆菌之间的交叉反应。然而，我们这位HLA - B27阴性的病例表明，除了HLA - B27之外，病因可能还包括多种因素。由于我们病例中观察到的虹膜睫状体炎临床表现与HLA - B27阳性病例并无差异，因此无论是否存在HLA - B27，与强直性脊柱炎相关的虹膜睫状体炎都被认为是同一病症。
