Chujo Masami, Mikami Ichiro, Takashima Shigemitsu, Saeki Toshiaki, Ohsumi Shozo, Aogi Kenjiro, Okamura Hitoshi
Graduate School of Health Sciences, Hiroshima University, 1-2-3 Kasumi, 734-8551 Minami-ku, Hiroshima, Japan.
Support Care Cancer. 2005 Jul;13(7):503-14. doi: 10.1007/s00520-004-0733-z. Epub 2004 Dec 3.
The effects of psychosocial group interventions on improving quality of life (QOL) for patients with recurrent breast cancer are not well known. The objective of this study was to assess the feasibility of a psychosocial group intervention in Japanese women with first recurrence of breast cancer.
The subjects were consecutively selected from among patients who were diagnosed with a first recurrence of breast cancer. We conducted a 6-week psychosocial group intervention. QOL was assessed using the Profile of Mood States (POMS), the Impact of Event Scale-Revised, the Mental Adjustment to Cancer (MAC) scale, and the European Organization for Research and the Treatment of Cancer (EORTC) Quality of Life Questionnaire-Cancer 30/Breast module 23 (QLQ-C30/Br23) at baseline then immediately and 3 and 6 months after completion of the intervention.
Among 58 eligible patients, written consent was obtained from 28 (48%), and the final evaluation was conducted on 19 subjects. The repeated measured analysis of variance (ANOVA) revealed a significant change in tension-anxiety, depression-dejection, anger-hostility and total mood disturbance on the POMS, helplessness/hopelessness on the MAC scale, and body image and future perspective on the QLQ-C30/Br23. Dunnett's test revealed a significant difference in these scores between baseline and 3 months after the intervention but no difference between baseline and 6 months after the intervention.
These results suggested the possibility of a short-term effectiveness of the intervention; however the results were inconclusive because of selected small samples.
心理社会群体干预对改善复发性乳腺癌患者生活质量（QOL）的影响尚不清楚。本研究的目的是评估心理社会群体干预对日本首次复发性乳腺癌女性患者的可行性。
研究对象连续选自被诊断为首次复发性乳腺癌的患者。我们进行了为期6周的心理社会群体干预。在基线时、干预结束后立即以及干预结束后3个月和6个月，使用情绪状态剖面图（POMS）、事件影响量表修订版、癌症心理适应（MAC）量表以及欧洲癌症研究与治疗组织（EORTC）生活质量问卷-癌症30/乳腺模块23（QLQ-C30/Br23）对生活质量进行评估。
在58名符合条件的患者中，28名（48%）获得了书面同意，对19名受试者进行了最终评估。重复测量方差分析（ANOVA）显示，POMS上的紧张焦虑、抑郁沮丧、愤怒敌意和总情绪紊乱、MAC量表上的无助/绝望以及QLQ-C30/Br23上的身体形象和未来展望有显著变化。Dunnett检验显示，干预后3个月与基线之间这些分数存在显著差异，但干预后6个月与基线之间无差异。
这些结果提示了干预短期有效性的可能性；然而，由于样本量小，结果尚无定论。
