Institute of Materials Engineering, Faculty of Science and Technology, University of Silesia, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
Institute of Physics, Faculty of Science and Technology, University of Silesia, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
Int J Mol Sci. 2024 Oct 21;25(20):11333. doi: 10.3390/ijms252011333.
This study investigates the degradation of six different types of absorbable surgical threads commonly used in clinical practice, focusing on their response to exposure to physiological fluids. The threads were subjected to hydrolytic and enzymatic degradation in physiological saline, bile, and pancreatic juice. Our findings demonstrate that bile and pancreatic juice, particularly when contaminated with bacterial strains such as , spp., and , significantly accelerate the degradation process. Using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and tensile strength testing, we observed distinct differences in the chemical structure and mechanical integrity of the sutures. Principal component analysis (PCA) of the FTIR spectra revealed that PDS threads exhibited the highest resistance to degradation, maintaining their mechanical properties for a longer duration compared with Monocryl and Vicryl. These results highlight the critical role of thread selection in gastrointestinal surgeries, where prolonged exposure to bile and pancreatic juice can compromise the suture integrity and lead to postoperative complications. The insights gained from this study will contribute to improving the selection and application of absorbable threads in clinical settings.
本研究调查了临床实践中常用的六种不同类型可吸收手术缝线的降解情况，重点关注它们对暴露于生理液中的反应。将缝线在生理盐水中、胆汁和胰液中进行水解和酶解降解。我们的研究结果表明，胆汁和胰液，特别是当受到如 、 spp. 和 等细菌菌株污染时，会显著加速降解过程。通过傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）和拉伸强度测试，我们观察到缝线的化学结构和机械完整性存在明显差异。FTIR 光谱的主成分分析（PCA）表明，PDS 缝线表现出最高的抗降解能力，与 Monocryl 和 Vicryl 相比，其机械性能能维持更长时间。这些结果强调了在胃肠道手术中缝线选择的重要性，因为长时间暴露于胆汁和胰液会损害缝线的完整性，并导致术后并发症。本研究的结果将有助于改善可吸收缝线在临床环境中的选择和应用。
