Mumby Dave G, Gaskin Stephane, Glenn Melissa J, Schramek Tania E, Lehmann Hugo
Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, H4B 1R6, Quebec, Canada.
Learn Mem. 2002 Mar-Apr;9(2):49-57. doi: 10.1101/lm.41302.
Rats have a natural tendency to spend more time exploring novel objects than familiar objects, and this preference can be used as an index of object recognition. Rats also show an exploratory preference for objects in locations where they have not previously encountered objects (an index of place memory) and for familiar objects in contexts different from those in which the objects were originally encountered (an index of context memory). In this experiment, rats with cytotoxic lesions of the hippocampal formation were tested on all three versions of the novelty-preference paradigm, with a 5-min retention interval between the familiarization and test phases. Rats with sham lesions displayed a novelty preference on all three trial types, whereas the rats with hippocampal lesions displayed a novelty preference on Object trials but did not discriminate between the objects on Place trials or Context trials. The findings indicate that hippocampal damage impairs memory for contextual or spatial aspects of an experience, whereas memory for objects that were part of the same experience are left relatively intact.
大鼠天生倾向于花更多时间探索新物体而非熟悉的物体，这种偏好可作为物体识别的指标。大鼠还表现出对其先前未遇到过物体的位置处的物体（位置记忆指标）以及与最初遇到物体的环境不同的环境中的熟悉物体（情境记忆指标）的探索偏好。在本实验中，对海马结构有细胞毒性损伤的大鼠在新颖性偏好范式的所有三个版本上进行测试，在熟悉阶段和测试阶段之间有5分钟的保持间隔。假损伤的大鼠在所有三种试验类型上都表现出新颖性偏好，而海马损伤的大鼠在物体试验上表现出新颖性偏好，但在位置试验或情境试验中不能区分物体。这些发现表明，海马损伤会损害对经历的情境或空间方面的记忆，而对同一经历中物体的记忆则相对保持完整。
