肾上皮细胞中的酸感应
Acid sensing in renal epithelial cells.
作者信息
Gluck Stephen L
机构信息
Division of Nephrology, UCSF, 513 Parnassus Avenue, Box 0532, San Francisco, California 94143-0532, USA.
出版信息
J Clin Invest. 2004 Dec;114(12):1696-9. doi: 10.1172/JCI23864.
Abstract
The kidney adjusts net acid excretion to match production with exquisite precision, despite little or no change in the plasma bicarbonate concentration. The acid-sensing pathway that signals the kidney to increase acid secretion involves activation of the proto-oncogene c-Src. A new study in this issue shows that proline-rich tyrosine kinase 2 (Pyk2) is responsible for acid-induced activation of c-Src and is essential for acid sensing in renal epithelial cells. The findings implicate a broader role for Pyk2 in acid-base homeostasis in bone and other tissues beyond the kidney.
摘要
尽管血浆碳酸氢盐浓度几乎没有变化，肾脏仍能精确地调节净酸排泄，使其与酸生成相匹配。向肾脏发出增加酸分泌信号的酸感应途径涉及原癌基因c-Src的激活。本期的一项新研究表明，富含脯氨酸的酪氨酸激酶2（Pyk2）负责酸诱导的c-Src激活，并且对肾上皮细胞的酸感应至关重要。这些发现表明，Pyk2在肾脏以外的骨骼和其他组织的酸碱平衡中具有更广泛的作用。
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本文引用的文献
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Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.慢性肾脏病与死亡、心血管事件及住院风险
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Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein.内皮素活性增加介导了饮食蛋白诱导的远端肾单位酸化增强。
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Regulation of endothelial cell function BY FAK and PYK2.黏着斑激酶（FAK）和脯氨酸酪氨酸激酶2（PYK2）对内皮细胞功能的调节
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Src kinase activity is essential for osteoclast function.Src激酶活性对于破骨细胞功能至关重要。
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