Sano Tomohiko, Kume Takuji, Fujimura Tsutomu, Kawada Hiromitsu, Moriwaki Shigeru, Takema Yasunori
Skin Care Research Laboratories, Kao Corporation, 2-1-3 Bunka Sumidaku, 131-8501, Tokyo, Japan.
Arch Dermatol Res. 2005 Feb;296(8):359-65. doi: 10.1007/s00403-004-0533-9. Epub 2004 Dec 14.
It has been reported that the formation of wrinkles involves changes in the elastic properties of the dermis due to the denaturation of elastic fibers. Several studies have shown that the hydration condition of the stratum corneum is also important in wrinkle formation. It is, however, still unclear how the stratum corneum contributes to wrinkle formation. Here we investigated the relationship between the formation of wrinkles and changes in the physical properties and condition of the skin after repetitive ultraviolet B (UVB) irradiation of hairless mice (HR/ICR). Repetitive UVB irradiation caused wrinkles on the dorsal skin of the mice. The elasticity (E') of the stratum corneum of UVB-irradiated mice was significantly lower than that of age-matched control (unirradiated) mice. UVB exposure also caused a deterioration of the fibrous ultrastructure of keratin intermediate filaments (KIFs) in the skin. We conclude that the deterioration of KIFs in the stratum corneum caused by repetitive UVB irradiation decreases the elastic properties of the stratum corneum, resulting in the formation of wrinkles.
据报道，皱纹的形成涉及由于弹性纤维变性导致的真皮弹性特性变化。多项研究表明，角质层的水合状态在皱纹形成中也很重要。然而，角质层如何促成皱纹形成仍不清楚。在此，我们研究了无毛小鼠（HR/ICR）经重复紫外线B（UVB）照射后皱纹形成与皮肤物理性质及状态变化之间的关系。重复UVB照射导致小鼠背部皮肤出现皱纹。UVB照射小鼠的角质层弹性（E'）显著低于年龄匹配的对照（未照射）小鼠。UVB暴露还导致皮肤中角蛋白中间丝（KIFs）的纤维超微结构恶化。我们得出结论，重复UVB照射引起的角质层中KIFs的恶化降低了角质层的弹性特性，从而导致皱纹形成。
