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口服 通过靶向c-Raf信号轴预防紫外线B诱导的皮肤衰老。

Oral Administration of Prevents UVB-Induced Skin Aging through Targeting the c-Raf Signaling Axis.

作者信息

Jo Seongin, Jung Young-Sung, Cho Ye-Ryeong, Seo Ji-Won, Lim Won-Chul, Nam Tae-Gyu, Lim Tae-Gyu, Byun Sanguine

机构信息

Department of Biotechnology, Yonsei University, Seoul 03722, Korea.

Korea Food Research Institute, Wanju-gun 55365, Korea.

出版信息

Antioxidants (Basel). 2021 Oct 22;10(11):1663. doi: 10.3390/antiox10111663.

DOI:10.3390/antiox10111663
PMID:34829534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8614869/
Abstract

is a widely used Rosa species for medicinal and culinary purposes. has been reported to display antioxidant, anti-inflammatory, and antibacterial activities. However, the effect of against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of prevented UVB-mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that downregulates UVB-induced COX-2 and MMP-1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC-MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by . Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c-Raf/MEK/ERK/c-Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB-induced MMP-1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, could be used as a functional ingredient in the development of nutraceuticals against skin aging.

摘要

是一种广泛用于药用和烹饪目的的蔷薇属物种。据报道，其具有抗氧化、抗炎和抗菌活性。然而，其在体内对皮肤衰老的影响尚不清楚，其活性成分也尚未完全了解。口服该物种可预防紫外线B（UVB）介导的小鼠背部皮肤皱纹形成以及胶原蛋白/角蛋白纤维的流失。在分子水平上对生物标志物的检测表明，该物种可下调皮肤中UVB诱导的环氧化酶-2（COX-2）和基质金属蛋白酶-1（MMP-1）的表达。通过使用超高效液相色谱-串联质谱（UHPLC-MS/MS）系统对鉴定出的主要化合物进行直接比较，我们发现没食子酸是该物种所表现出的抗皮肤衰老作用的主要成分。对分子机制的研究表明，没食子酸可以有效且选择性地靶向c-Raf/丝裂原活化蛋白激酶/细胞外信号调节激酶/c-Fos信号轴。此外，在重建的三维人体皮肤模型中，没食子酸和丝裂原活化蛋白激酶抑制剂均可阻断UVB诱导的MMP-1表达并恢复胶原蛋白水平。总体而言，该物种可作为一种功能性成分用于开发抗皮肤衰老的营养保健品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/203428d656fe/antioxidants-10-01663-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/2d98589076dd/antioxidants-10-01663-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/78631ed60d5c/antioxidants-10-01663-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/f19fc1e1f4a2/antioxidants-10-01663-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/768fb1320443/antioxidants-10-01663-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/74974ca1501b/antioxidants-10-01663-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/c3136e8088e7/antioxidants-10-01663-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/203428d656fe/antioxidants-10-01663-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/2d98589076dd/antioxidants-10-01663-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/a4228fc49f28/antioxidants-10-01663-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/78631ed60d5c/antioxidants-10-01663-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/f19fc1e1f4a2/antioxidants-10-01663-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42cc/8614869/768fb1320443/antioxidants-10-01663-g005.jpg
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