Oral Administration of Prevents UVB-Induced Skin Aging through Targeting the c-Raf Signaling Axis.

is a widely used Rosa species for medicinal and culinary purposes. has been reported to display antioxidant, anti-inflammatory, and antibacterial activities. However, the effect of against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of prevented UVB-mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that downregulates UVB-induced COX-2 and MMP-1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC-MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by . Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c-Raf/MEK/ERK/c-Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB-induced MMP-1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, could be used as a functional ingredient in the development of nutraceuticals against skin aging.