Maggi S, Noale M, Gallina P, Marzari C, Bianchi D, Limongi F, Crepaldi G
CNR Institute of Neuroscience, Center on Aging, c/o Clinica Medica 1(o), University of Padua, Via Giustiniani 2, 35128 Padova, Italy.
Diabetologia. 2004 Nov;47(11):1957-62. doi: 10.1007/s00125-004-1555-8. Epub 2004 Dec 1.
AIMS/HYPOTHESIS: We studied the role of diabetic complications and comorbidity in the association between diabetes and disability in the elderly.
Data were from a nationally representative sample of 5632 older Italians, aged 65 years and older, and who participated in the Italian Longitudinal Study on Aging. Clinical diagnoses of diabetes and other major chronic conditions were made by a physician, while disability was assessed by self-reported information on activities of daily living and physical performance tests.
After adjusting for age, education and BMI, disability on the basis of activities of daily living was associated with diabetes in women, but not in men (odds ratio [OR] 1.65, CI: 1.22-2.23 and OR 1.21, CI: 0.84-1.75 respectively). In contrast, the association between severe and/or total disability on the basis of physical performance tests and diabetes was strong in both sexes (OR 2.81, CI: 1.44-5.41 and OR 2.16, CI: 1.25-3.73 respectively). Adjusting for traditional complications and comorbidity reduced the excess odds of disability by 38% in women and by 16% in men.
CONCLUSIONS/INTERPRETATION: Disability in older Italians with diabetes is frequent and only partially attributable to traditional diabetic complications and comorbidity.
目的/假设：我们研究了糖尿病并发症和合并症在老年人糖尿病与残疾关联中的作用。
数据来自5632名年龄在65岁及以上的意大利老年人的全国代表性样本，他们参与了意大利老龄化纵向研究。糖尿病和其他主要慢性病的临床诊断由医生做出，而残疾情况通过关于日常生活活动的自我报告信息和身体机能测试进行评估。
在调整年龄、教育程度和体重指数后，基于日常生活活动的残疾在女性中与糖尿病相关，而在男性中则不然（优势比[OR]分别为1.65，CI：1.22 - 2.23和OR 1.21，CI：0.84 - 1.75）。相比之下，基于身体机能测试的严重和/或完全残疾与糖尿病之间的关联在两性中都很强（OR分别为2.81，CI：1.44 - 5.41和OR 2.16，CI：1.25 - 3.73）。调整传统并发症和合并症后，女性残疾的额外优势比降低了38%，男性降低了16%。
结论/解读：患有糖尿病的意大利老年人中残疾情况很常见，且仅部分归因于传统的糖尿病并发症和合并症。
