理解临床试验中的治疗效果测量指标。
Understanding measures of treatment effect in clinical trials.
作者信息
Akobeng A K
机构信息
Department of Paediatric Gastroenterology, Central Manchester and Manchester Children's University Hospitals, Charlestown Road, Blackley, Manchester M9 7AA, UK.
出版信息
Arch Dis Child. 2005 Jan;90(1):54-6. doi: 10.1136/adc.2004.052233.
Evidence based medicine implies that healthcare professionals are expected to base their practice on the best available evidence. This means that we should acquire the necessary skills for appraising the medical literature, including the ability to understand and interpret the results of published articles. This article discusses in a simple, practical, 'non-statistician' fashion some of the important outcome measures used to report clinical trials comparing different treatments or interventions. Absolute and relative risk measures are explained, and their merits and demerits discussed. The article aims to encourage healthcare professionals to appreciate the use and misuse of these outcome measures and to empower them to calculate these measures themselves when, as is frequently the case, the authors of some original articles fail to present their results in a more clinically friendly format.
循证医学意味着医疗保健专业人员应依据可得的最佳证据开展实践。这意味着我们应掌握评估医学文献的必要技能，包括理解和解读已发表文章结果的能力。本文以一种简单、实用的“非统计学家”方式，探讨了用于报告比较不同治疗方法或干预措施的临床试验的一些重要结局指标。解释了绝对风险和相对风险指标，并讨论了它们的优缺点。本文旨在鼓励医疗保健专业人员认识到这些结局指标的正确使用和误用情况，并使他们有能力在许多原创文章的作者未以更便于临床应用的格式呈现结果时，自行计算这些指标。
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