在绝经后早期骨质减少的女性中，习惯性体育活动、非运动性锻炼、肌肉力量和最大摄氧量对骨密度的影响相当低。

The effect of habitual physical activity, non-athletic exercise, muscle strength, and VO2max on bone mineral density is rather low in early postmenopausal osteopenic women.

作者信息

Kemmler W, Weineck J, Kalender W A, Engelke K

机构信息

Institute of Medical Physics, University of Erlangen, Germany.

出版信息

J Musculoskelet Neuronal Interact. 2004 Sep;4(3):325-34.

PMID:15615501

Abstract

CONTEXT

Although the positive effect of well-designed exercise regimes on bone mineral density (BMD) is established the osteo-anabolic relevance of habitual physical activity and non-athletic exercise is still under discussion.

OBJECTIVE

To determine the effects of habitual physical activity, non-athletic exercise muscle strength, VO2max and anthropometric parameters on BMD in early post-menopausal women.

DESIGN

Cross-sectional study.

METHODS

150 early postmenopausal women (55.5+/-3.4 years), which were free of diseases or medication affecting bone metabolism and had no athletic history were investigated. The influence of weight, body composition, physical activity, isometric strength, VO2max, and nutritional intake on BMD was measured at multiple sites using different techniques. Further bone markers (Osteocalcin, CTX) were determined. Activity and weight-bearing activity were assessed by questionnaire. Maximum strength was measured isometrically. Aerobic capacity was measured with an spirometric system in a stepwise treadmill test and dietary intake was monitored over 5 days.

RESULTS

Slight relationships between physical activity, exercise, muscle strength and VO2max with bone parameters were determined by univariate analysis. After adjusting for confounding variables in a stepwise regression analysis, significant relationships with BMD measured at the hip or the spine could no longer be detected for physical activity, exercise, and physical fitness (strength indices, VO2max). The same was true for osteocalcin and CTX. Arm strength explained 4.5% of the variation of forearm BMD (DXA). At the calcaneal site, osteogenic exercise was significantly related to the quantitative ultrasound index (r2 = 0.27).

CONCLUSION

The isolated effect of habitual physical activity, unspecific exercise participation, and muscle strength on bone parameters is rather low in (early-) postmenopausal women.

CLINICAL RELEVANCE

Women at risk should take specific exercise programs into consideration rather than to increasing the amount of habitual physical activity.

摘要

背景

尽管精心设计的运动方案对骨密度（BMD）的积极作用已得到证实，但习惯性体力活动和非竞技性运动对骨合成代谢的相关性仍在讨论中。

目的

确定习惯性体力活动、非竞技性运动、肌肉力量、最大摄氧量（VO2max）和人体测量参数对绝经后早期女性骨密度的影响。

设计

横断面研究。

方法

对150名绝经后早期女性（55.5±3.4岁）进行调查，这些女性无影响骨代谢的疾病或药物治疗史，也无运动史。采用不同技术在多个部位测量体重、身体成分、体力活动、等长肌力、VO2max和营养摄入对骨密度的影响。还测定了其他骨标志物（骨钙素、CTX）。通过问卷调查评估活动和负重活动。等长测量最大力量。在逐步递增的跑步机测试中用肺活量测定系统测量有氧能力，并对饮食摄入进行5天的监测。

结果

单因素分析确定了体力活动、运动、肌肉力量和VO2max与骨参数之间存在轻微关系。在逐步回归分析中对混杂变量进行校正后，体力活动、运动和体能（力量指数、VO2max）与髋部或脊柱测量的骨密度之间不再存在显著关系。骨钙素和CTX也是如此。手臂力量解释了前臂骨密度（双能X线吸收法）变化的4.5%。在跟骨部位，成骨运动与定量超声指数显著相关（r2 = 0.27）。