Triplett D A
Department of Pathology, Indiana University School of Medicine, Indianapolis.
Stroke. 1992 Feb;23(2 Suppl):I11-4.
Several coagulation assays identify lupus anticoagulants, but there is no uniform opinion regarding minimum criteria for the diagnosis or the most sensitive procedure to be used to screen for lupus anticoagulants. Based on test availability and the cumulative literature, a sensitive activated partial thromboplastin time appears to be the most appropriate screening test. The dilute Russell's viper venom time may be used as both a screening and a confirmatory procedure. The platelet neutralization procedure is the most sensitive and specific of the confirmatory procedures that use an increased amount of phospholipid to either "bypass" or "neutralize" the lupus anticoagulant.
有几种凝血检测方法可识别狼疮抗凝物，但对于狼疮抗凝物诊断的最低标准或用于筛查狼疮抗凝物的最敏感检测方法，尚无统一意见。根据检测方法的可用性和累积文献，活化部分凝血活酶时间似乎是最合适的筛查检测。稀释蝰蛇毒时间可用作筛查和确证检测。血小板中和试验是确证检测中最敏感和特异的，这些确证检测使用增加量的磷脂来“绕过”或“中和”狼疮抗凝物。
