Watson R, Bakos L, Compton P, Gawin F
New Haven Sleep Disorders Center, Connecticut 06511.
Am J Drug Alcohol Abuse. 1992;18(1):21-8. doi: 10.3109/00952999209001608.
Three recreational cocaine users (age, 26.7 years), after one adaptation night, spent 5 days and nights in the laboratory where their EEG, EOG, and submental EMG were recorded during all of their sleep. On the second afternoon and evening of the study, subjects used an estimated 1 to 2 g cocaine intranasally. They all slept between 2:00 A.M. and 9:00 A.M. that night. Blood samples were drawn each evening and morning. Absolute plasma cocaine levels and patterns of elimination were consistent with subjects report of dose and time of administration. Mood ratings were made repeatedly throughout the study. There was suppression of REM sleep during the use of cocaine followed by a rebound which is specific to REM sleep and is not seen in other stages of sleep. REM variables subsided to normal levels on the third recovery night following cocaine use.
三名娱乐性可卡因使用者（年龄26.7岁），经过一个适应夜后，在实验室度过了5个日夜，期间在他们所有睡眠阶段记录脑电图（EEG）、眼电图（EOG）和颏下肌电图（EMG）。在研究的第二个下午和晚上，受试者经鼻使用了估计1至2克可卡因。当晚他们都在凌晨2点至上午9点之间入睡。每天早晚采集血样。血浆可卡因绝对水平和消除模式与受试者报告的给药剂量和时间一致。在整个研究过程中反复进行情绪评分。使用可卡因期间快速眼动（REM）睡眠受到抑制，随后出现REM睡眠特有的反弹，在其他睡眠阶段未见此现象。使用可卡因后的第三个恢复夜，REM变量恢复到正常水平。
