Davidson S F, Brantley S K, Das S K
Department of Surgery, University of Mississippi Medical Center, Jackson.
Br J Plast Surg. 1992 Feb-Mar;45(2):109-12. doi: 10.1016/0007-1226(92)90168-w.
Investigations in our laboratory showed that exposure to ultraviolet radiation significantly diminishes wound tensile strength in hairless guinea pigs. A recurring question is whether changes in wound tensile strength are reversible. The present project addresses whether wound tensile strength in irradiated and control animals differs following a 90-day healing period after irradiation and wounding. Group 1 animals (n = 10) served as nonirradiated controls. Group 2 animals (n = 10) were irradiated with a UVA/B source receiving a cumulative dose of 8,960 joules/cm2 over a 16-week period. Following completion of the irradiation schedule, a standard 6 cm midline incision was made on the dorsum of each animal and then allowed to heal for 90 days. At this time, wound tensile strength measurements were performed. The mean wound tensile strength value for the control group (4.62 +/- 0.16) was not significantly different compared to the irradiated animals (4.23 +/- 0.24). The alteration in wound tensile strength observed at 21 days in animals irradiated with a UVA/B light source is reversible after a 90-day recovery period.
我们实验室的研究表明，暴露于紫外线辐射会显著降低无毛豚鼠伤口的抗张强度。一个反复出现的问题是伤口抗张强度的变化是否可逆。本项目探讨了在照射和受伤后的90天愈合期后，照射组和对照组动物的伤口抗张强度是否存在差异。第1组动物（n = 10）作为未照射的对照组。第2组动物（n = 10）用UVA/B光源进行照射，在16周内接受的累积剂量为8960焦耳/平方厘米。在完成照射方案后，在每只动物的背部做一个标准的6厘米中线切口，然后让其愈合90天。此时，进行伤口抗张强度测量。对照组的平均伤口抗张强度值（4.62 +/- 0.16）与照射组动物（4.23 +/- 0.24）相比无显著差异。在用UVA/B光源照射的动物中，在21天时观察到的伤口抗张强度变化在90天的恢复期后是可逆的。
