Otterson M F, Sarna S K, Lee M B
Department of Surgery, Medical College of Wisconsin, Milwaukee.
Dig Dis Sci. 1992 May;37(5):709-15. doi: 10.1007/BF01296427.
We investigated the effects of total abdominal fractionated irradiation on postprandial small intestinal motor activity in five dogs. Five strain-gauge transducers were attached to the seromuscular layer of the duodenum, jejunum, and ileum of each dog to record circular muscle contractions. Radiation (250 cGy) was administered three times a week on alternate days for three successive weeks (total dose, 2250 cGy). Postprandial 4-hr recordings were made once each week during radiation and at one and three weeks following completion of radiation. Duodenal mean amplitude and area under contractions did not change during or following the radiation schedule, but the mean frequency and duration of duodenal contractions decreased during the radiation schedule. Both parameters returned to baseline values postirradiation. Jejunal mean duration, amplitude, area, and frequency of contractions decreased during radiation; mean amplitude and area returned to baseline values postirradiation but not the duration and frequency of contractions. All parameters of ileal contractions decreased during radiation, and all but area and amplitudes remained depressed postirradiation. Significantly decreased strength and frequency of contractions, particularly in the jejunum and ileum occur during and following irradiation. These changes may potentially alter transit time.
我们研究了全腹分次照射对5只犬餐后小肠运动活性的影响。在每只犬的十二指肠、空肠和回肠的浆肌层附着5个应变片式传感器，以记录环行肌收缩情况。每周隔日进行3次照射（每次250 cGy），连续照射3周（总剂量2250 cGy）。在照射期间每周进行1次餐后4小时记录，并在照射结束后1周和3周各进行1次记录。十二指肠收缩的平均幅度和收缩曲线下面积在照射期间及照射后均未改变，但十二指肠收缩的平均频率和持续时间在照射期间降低。照射后这两个参数均恢复至基线值。空肠收缩的平均持续时间、幅度、面积和频率在照射期间降低；照射后平均幅度和面积恢复至基线值，但收缩的持续时间和频率未恢复。回肠收缩的所有参数在照射期间均降低，照射后除面积和幅度外，其余参数仍低于正常。照射期间及照射后，尤其是空肠和回肠，收缩强度和频率显著降低。这些变化可能会改变转运时间。
