Fraser R, Frisby C, Schirmer M, Blackshaw A, Langman J, Yeoh E, Rowland R, Horowitz M
Department of Medicine, Royal Adelaide Hospital, North Tce, South Australia.
Acta Oncol. 1997;36(7):705-10. doi: 10.3109/02841869709001341.
Disordered small intestinal motility occurs frequently during acute radiation enteritis. However, the characteristics and time course of the motor dysfunction are poorly defined. These parameters were assessed in a novel animal model of radiation enteritis. Ileal pressures were recorded in vitro with perfused micromanometric catheter using an arterially perfused ileal loop in 22 ferrets following fractionated abdominal irradiation (9 doses 2.50 Gy thrice weekly for 3 weeks). Tissue damage was graded histologically. Studies were performed 3 to 29 days after irradiation. Tissue from 7 control animals was also studied. All treated animals developed diarrhoea. Histology showed changes consistent with mild to moderate radiation enteritis. Following irradiation, there was an initial increase in frequency followed by a non-significant reduction in the frequency, but not the amplitude of ileal pressure waves. The frequency of pressure waves showed an inverse relationship with time after radiation (r = -0.634, p < 0.002). There was no relationship between motility and histology. We conclude that abdominal irradiation is associated with a time-dependent reduction in ileal motility which does not correlate with light microscopic changes.
急性放射性肠炎期间小肠动力紊乱频繁发生。然而，运动功能障碍的特征和时间进程尚不清楚。在一种新型放射性肠炎动物模型中对这些参数进行了评估。在22只雪貂接受分次腹部照射（9次剂量，每次2.50 Gy，每周3次，共3周）后，使用动脉灌注回肠袢，通过灌注微测压导管在体外记录回肠压力。组织损伤进行组织学分级。在照射后3至29天进行研究。还研究了7只对照动物的组织。所有接受治疗的动物均出现腹泻。组织学显示与轻度至中度放射性肠炎一致的变化。照射后，回肠压力波频率最初增加，随后频率无显著降低，但波幅无变化。压力波频率与照射后的时间呈负相关（r = -0.634，p < 0.002）。运动与组织学之间无相关性。我们得出结论，腹部照射与回肠蠕动随时间的减少有关，这与光学显微镜下的变化无关。
