Govindarajan Raghavan, Vijayakumar Madhavan, Rao Chandana Venkateshwara, Shirwaikar Annie, Mehrotra Shanta, Pushpangadan Palpu
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow-226 001, India.
Acta Pharm. 2004 Dec;54(4):331-8.
Wound healing potential of ethanolic extract of Anogeissus latifolia bark (ALE) for treatment of dermal wounds in rats was studied on excision and incision wound models. HPTLC of the total extract was recorded for the purpose of standardization. Various parameters of incision wound, viz. epithelization period, scar area, tensile strength and hydroxyproline measurements along with wound contraction, were used to evaluate the effect of A. latifolia on wound healing. The results obtained indicate that A. latifolia accelerates the wound healing process by decreasing the surface area of the wound and increasing the tensile strength. Nitrofurazone ointment was used as a positive control. Complete epithelization was observed within 15 days with ALE. Measurements of the healed area and the hydroxyproline level were in agreement. Antibacterial activity of ALE was studied against Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae) compared to erythromycin and tetracycline. Moderate activity was observed against all organisms. The present study provides a scientific rationale for the traditional use of Anogeissus latifolia in the management of skin diseases such as sores, boils and itching.
在切除和切口伤口模型上研究了阔叶香须树树皮乙醇提取物（ALE）对大鼠皮肤伤口的愈合潜力。为了标准化的目的，记录了总提取物的高效薄层色谱。使用切口伤口的各种参数，即上皮化期、疤痕面积、抗张强度和羟脯氨酸测量以及伤口收缩，来评估阔叶香须树对伤口愈合的影响。获得的结果表明，阔叶香须树通过减小伤口表面积和增加抗张强度来加速伤口愈合过程。呋喃西林软膏用作阳性对照。使用ALE在15天内观察到完全上皮化。愈合面积和羟脯氨酸水平的测量结果一致。与红霉素和四环素相比，研究了ALE对革兰氏阳性菌（金黄色葡萄球菌）和革兰氏阴性菌（大肠杆菌、铜绿假单胞菌和肺炎克雷伯菌）的抗菌活性。观察到对所有生物体都有中等活性。本研究为传统上使用阔叶香须树治疗诸如疮、疖和瘙痒等皮肤病提供了科学依据。
