凝胶对大鼠切除伤口的愈合作用
Wound Healing Effect of gel on Excisional Wounds in Rats.
作者信息
Mohsenikia Maryam, Khakpour Shahrzad, Azizian Zahra, Ashkani-Esfahani Soheil, Razavipour Seyyede Tahereh, Toghiani Pooya
机构信息
Young Researchers and Elit Club, Tehran Medial Sciences Branch, Islamic Azad University, Tehran, Iran.
Department of Physiology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
出版信息
Adv Biomed Res. 2017 Jan 31;6:2. doi: 10.4103/2277-9175.199260. eCollection 2017.
BACKGROUND
Wound healing is a complex process leading to regeneration of damaged skin tissue. (AE) have many effective activities such as anti-inflammatory, antimicrobial, antioxidative, and anti-tumoral effects. The extract of AE has positive effects on burn wounds. This study is designed to investigate the healing effects of AE on excisional wounds in rats.
MATERIALS AND METHODS
Thirty six rats with the age of 8 weeks divided into three groups. One group (E1) was treated with AE gel at a concentration of 10%. Control group (C1) received normal saline and the vehicle group (C2) was treated with carboxymethyl cellulose gel as the vehicle for 14 days. Stereological analysis was done to investigate the collagen bundle and hair follicale synthesis, vascularization, fibroblast proliferation. Pathological evaluation was also conducted.
RESULTS
In this study, pathological evaluation showed severe acute inflammation in C2 group, chronic and acute inflammation in C1 and also more wound contraction in E1 in comparison with other groups. There was a meaningful difference between E1 and C1 regarding fibroblast proliferation ( < 0.05).
CONCLUSION
Results of this study revealed the healing effect of AE on excisional wounds and recommend its administration after further clinical investigations.
背景
伤口愈合是一个导致受损皮肤组织再生的复杂过程。芦荟提取物（AE）具有许多有效活性，如抗炎、抗菌、抗氧化和抗肿瘤作用。AE提取物对烧伤创面有积极作用。本研究旨在探讨AE对大鼠切除伤口的愈合效果。
材料与方法
将36只8周龄大鼠分为三组。一组（E1）用10%浓度的AE凝胶治疗。对照组（C1）接受生理盐水，赋形剂组（C2）用羧甲基纤维素凝胶作为赋形剂治疗14天。进行体视学分析以研究胶原束和毛囊合成、血管生成、成纤维细胞增殖。还进行了病理评估。
结果
在本研究中，病理评估显示C2组有严重急性炎症，C1组有慢性和急性炎症，且与其他组相比，E1组伤口收缩更多。E1组和成纤维细胞增殖之间在C1组有显著差异（P<0.05）。
结论
本研究结果揭示了AE对切除伤口的愈合作用，并建议在进一步临床研究后使用。
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